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Aging · Observational Study
ClinicalTrials.gov · August 4, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned observational study registered at ClinicalTrials.gov to track amyloid accumulation and cognitive decline in older adults over 5 years using serial PET imaging. No results have been reported in this registry record; the study is currently recruiting.
Observational. Aging; age from 55 Years; to 110 Years; accepts healthy volunteers. Intervention: Adults aged 55 and older.. n = 400. 1 site: United States.
This is a planned observational study registered at ClinicalTrials.gov to track amyloid accumulation and cognitive decline in older adults over 5 years using serial PET imaging. No results have been reported in this registry record; the study is currently recruiting.
This is a registry record with no results posted; no efficacy, safety, or outcome data are available.
The source did not state who this applies to in practice.
This is a registry record for an ongoing observational study with no reported results; it describes planned enrollment and methods only.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07099053). This is a study registration, not published results. Lead sponsor: National Institute on Aging (NIA). Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 400 participants (ESTIMATED). Conditions: Aging. Primary outcome measures: Amyloid accumulation , longitudinal. Brief summary: Background: Some people experience cognitive decline as they age. That is, they lose memory, problem-solving, and other mental abilities. Amyloids are groups of proteins that develop in the brain and increase in number as people age. Researchers want to use imaging scans to track amyloids in people s brains over time. Their goal is to find out if any changes are related to cognitive decline or other medical issues. Objective: To learn how amyloids may affect brain structure and function as people age. Eligibility: People aged 55 years and older who are enrolled in the Baltimore Longitudinal Study of Aging. Design: Participants will have imaging scans and other tests every 1 to 4 years, depending on their age. Those 80 and older will be scanned yearly. These scans will be done during regular BLSA visits. The scans will be positron emission tomography and computed tomography (PET CT). Participants will be given fluid through a tube inserted into a vein in their arm. The fluid is a tracer that will cause the amyloids to light up in the images. Then they will lie on a bed with their head inside a PET CT scanner. They will lie still for about 30 minutes. Participants will have tests to assess their memory and other mental skills. They will answer questions about their mood and daily life. These tests will take about 40 minutes to complete; they may be done in person or by phone. Participants will give a contact number for someone who can answer questions about the participant s daily routine. These questions may be answered in person or by phone. Participants will be in this study for 5 years.
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