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Insulin Sensitivity / Glucose Intolerance / Reduced fat dairy · Interventional Study
ClinicalTrials.gov · August 11, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed randomized controlled trial registered on ClinicalTrials.gov comparing reduced-fat dairy, regular-fat dairy, and limited dairy on insulin sensitivity in adults with prediabetes. No results are posted in this registry record, so no clinical inferences can yet be drawn.
Interventional, Randomized, Parallel, Single masking, Treatment purpose. Insulin Sensitivity, Glucose Intolerance, PreDiabetes; age from 30 Years; to 65 Years; accepts healthy volunteers. Intervention: 2-3 servings/day reduced-fat; 2-3 servings/day regular-fat. Compared with: ≤1 dairy serving/day — No Intervention. n = 60. 1 site: Canada.
This is a completed randomized controlled trial registered on ClinicalTrials.gov comparing reduced-fat dairy, regular-fat dairy, and limited dairy on insulin sensitivity in adults with prediabetes. No results are posted in this registry record, so no clinical inferences can yet be drawn.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a completed registry record with no results posted; the study design is sound (randomized, controlled) but outcome data are not yet reported, making it a preliminary communication of a planned intervention study.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05421390). This is a study registration, not published results. Lead sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ACTUAL). Conditions: Insulin Sensitivity, Glucose Intolerance, PreDiabetes. Interventions: OTHER: Reduced fat dairy; OTHER: Regular fat dairy. Primary outcome measures: Change in whole-body insulin sensitivity , Difference between baseline and 12-weeks intervention visit. Brief summary: The objective of the study is to determine the effect of dairy consumption on insulin sensitivity in overweight and obese adults with prediabetes. Men and women (30-65 y) will be recruited from the greater Montreal area. Upon screening, those with prediabetes will complete a 2-wk run-in period in which participants will consume 1 serving/d of reduced-fat dairy. Adherent participants will be randomized by sex into 1 of 3 groups: ≤1 serving/d of dairy (limited dairy) or 2-3 servings/d of reduced-fat or regular-fat dairy for 12 weeks. Participants will be instructed on how to incorporate foods into their diet in a manner that prevents changes in their body weight. The hyperinsulinemic-euglycemic clamp will be used before and after the intervention to document potential changes in insulin sensitivity as the primary outcome. In addition, glycemic variables, body composition, and cardiometabolic risk factors will be assessed as secondary outcomes. Serum lipidomic and global gene expression responses to the intervention in subcutaneous adipose tissue will be measured as exploratory variables. Adherence to intervention will be assessed at each visit by food diaries, a record of consumed dairy products, and serum proportion of 15:0, 17:0, and t16:1n7 fatty acids as objective biomarkers of dairy fat intake.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.