Loading
Prediabetes / Type 2 Diabetes Mellitus · Journal article
Journal of Diabetes and Metabolic Disorders · August 7, 2026
Reinforces what was already believed, rather than introducing something new.
This cross-sectional study of 1,029 first-degree relatives of people with type 2 diabetes found substantial burden of prediabetes (18.0–30.9%) and diabetes (2.3–6.7%) depending on diagnostic criterion used. The three standard criteria (FPG, 2-hour OGTT, HbA1c) showed fair-to-moderate agreement, with FPG performing least well and HbA1c offering practical feasibility for screening high-risk groups.
Cross-sectional comparative study. First-degree relatives of people with type 2 diabetes mellitus. Compared with: Three diagnostic criteria: fasting plasma glucose (FPG), 2-hour oral glucose tolerance test (OGTT), and HbA1c. n = 1,029.
Prediabetes prevalence: 18.4% (FPG), 18.0% (2-hour OGTT), 30.9% (HbA1c) Diabetes prevalence: 2.3% (FPG), 6.0% (2-hour OGTT), 6.7% (HbA1c) When using a single diagnostic criterion, undiagnosed diabetes was 9.2% and prediabetes was 39.1%
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians screening high-risk relatives should recognize substantial prevalence of dysglycemia and understand that choice of diagnostic criterion (FPG, OGTT, HbA1c) materially affects detection rates. HbA1c may offer practical advantages for large-scale screening despite lower detection of prediabetes than 2-hour OGTT.
Cross-sectional prevalence study in a well-defined high-risk population using standard diagnostic criteria; confirms known epidemiology and relative performance of screening methods without a novel intervention or discovery.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians screening high-risk relatives should recognize substantial prevalence of dysglycemia and understand that choice of diagnostic criterion (FPG, OGTT, HbA1c) materially affects detection rates. HbA1c may offer practical advantages for large-scale screening despite lower detection of prediabetes than 2-hour OGTT.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background. First-degree relatives (FDRs) of people with type 2 diabetes mellitus (T2DM) are considered as a high-risk group to develop T2DM. This study aimed to determine the prevalence of prediabetes and diabetes and assess the agreement among three standard diagnostic criteria in this population.Methods. A cross-sectional study of 1,029 FDRs of people with T2DM was conducted. Anthropometric, blood pressure, and biochemical assessments, including fasting plasma glucose (FPG), HbA1c, lipid profile, and a 2-hour oral glucose tolerance test (OGTT), were performed. Agreement between diagnostic criteria was assessed using kappa statistics, and multivariable logistic regression identified the factors associated with dysglycemia.Results. According to a single diagnostic criterion, the prevalence of diabetes and prediabetes in FDRs with undiagnosed diabetes was 9.2% and 39.1%, respectively. Prediabetes prevalence based on FPG, 2-hour OGTT (2-h PG), and HbA1c was 18.4%, 18.0%, and 30.9%, respectively; while diabetes was identified in 2.3%, 6.0%, and 6.7% of the population. The three criteria showed fair-to-moderate agreement, with the highest concordance between 2-h PG and HbA1c. Older age, overweight/obesity, and hypertension were associated with higher odds for both conditions. In addition, men were at higher risk of diabetes than women.Conclusion. Our findings support a substantial burden of prediabetes and diabetes among FDRs of people with T2DM. Among the three standard criteria, FPG showed the lowest diagnostic performance to detect prediabetes and diabetes. While OGTT has practical limitations, HbA1c represents a feasible and informative tool for large-scale screening in high-risk groups.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.