Cancer, Hypoxia, and Metabolism · Journal article

The function of phosphoglycerate mutase 1 (PGAM1) and its role in diseases

Frontiers in Molecular Biosciences · August 17, 2026

Hypothesis-Generating Why this matters to you Expert discussion

Raises a question worth testing. It does not answer one.

AI Summary

This is a narrative review of PGAM1 biology, function, and disease associations without original data or clinical trial results. The source describes PGAM1 as upregulated in cancers and proposes it as a therapeutic target and diagnostic biomarker, but does not report comparative effectiveness, outcomes, or inhibitor efficacy in humans.

What was studied

Journal article. Implied: human cancer cells and tumors; no actual patient cohort studied.

Key findings

PGAM1 is upregulated in numerous human cancers PGAM1 promotes cell proliferation, invasion, and drug resistance PGAM1 serves as a biomarker for tumor diagnosis

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

The source did not state who this applies to in practice.

Plain-language summary

This is a narrative review synthesizing mechanistic knowledge about PGAM1 structure, function, and disease associations without reporting original experimental data, clinical outcomes, or comparative evidence.

Caveats

No quantitative efficacy data for PGAM1 inhibitors reported
No clinical trial results or patient outcomes presented
No comparative effect sizes or confidence intervals provided
Review scope and search strategy not specified; generalizability unclear

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

insufficient

Review article; no primary study design reported.

Directness

limited

Discusses mechanistic roles and biomarker potential without clinical endpoint data.

Consistency

insufficient

No comparison of conflicting evidence or systematic synthesis reported.

Risk of bias

insufficient

Review format; no assessment of included studies' bias provided.

Sample adequacy

insufficient

No empirical sample; narrative synthesis of existing literature.

What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.

Source abstract

Phosphoglycerate mutase 1 (PGAM1) is a pivotal metabolic enzyme during the process of glycolysis, catalyzing the interconversion between 3-phosphoglycerate and 2-phosphoglycerate. PGAM1 is mainly involved in cellular energy metabolism and biosynthesis, it is generally upregulated in numerous human cancers and promotes cell proliferation, invasion, and drug resistance. It serves as a significant biomarker for tumor diagnosis and a potential therapeutic target. In this paper, the basic structure and functions of PGAM1 and its family members, metabolic, non-metabolic activity and the regulatory mechanisms of PGAM1 and its correlation with diseases, as well as the latest progress of PGAM1 inhibitors in tumor diagnosis and treatment are introduced, aiming to provide new ideas for the targeted therapy of related diseases.

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梁慧芳Kaiming ZhangAihong PengJunqin LiYuanjun YaoCancer, Hypoxia, and Metabolism