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Epigenetics and DNA Methylation / Cancer, Hypoxia, and Metabolism / Immune Cells in Cancer · Journal article
Theoretical and Natural Science · September 8, 2026
Raises a question worth testing. It does not answer one.
This is a narrative review synthesizing mechanistic knowledge about protein lactylation as a post-translational modification linked to cancer pathways including proliferation, metastasis, angiogenesis, and immune evasion. The source proposes lactylation as a potential therapeutic target or sensitizer but reports no empirical results, clinical outcomes, or effect sizes to support clinical application.
Narrative review.
Protein lactylation is a newly described PTM that bridges glycolytic metabolism to epigenetic modifications in cancer Lactylation associated with multiple cancer phenotypes: survival, proliferation, metastasis, angiogenesis, vasculogenic mimicry, stemness, and immune evasion Lactylation-induced resistance mechanisms identified; emerging therapeutic opportunities proposed as sensitizer in combination therapy
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
A narrative review of mechanistic pathways linking protein lactylation to cancer phenotypes; raises questions about therapeutic potential but reports no empirical data, effect sizes, or clinical outcomes.
As stated by the source record.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
Protein lactylation is a newly described post-translational modification (PTM), initiated by the transfer of lactyl group in lactyl-CoA to lysine residues, and can be classified into histone and non-histone lactylation. Lactylation bridges glycolytic metabolism pathways to epigenetic modifications, complementing knowledge in both parts of cancer regulation. Here, we systemically review the recent advances in understanding the effects of lactylation on cancer, including survival, proliferation, metastasis, angiogenesis and vasculogenic mimicry, stemness and immune evasion. We also summarized lactylation-induced resistance mechanisms and emerging therapeutic opportunities, which may contribute to its integration in current therapies as a sensitizer.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.