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CBT-DAY (Cognitive Behavioral Therapy for Depression in Autistic Youth) / Treatment-as-Usual (TAU) / Anxiety Disorders · Interventional Study
ClinicalTrials.gov · August 10, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned randomized controlled trial comparing CBT-DAY to treatment-as-usual in autistic youth with depression. No results have been posted to the registry; this record describes the study design and planned enrollment only. Recruitment has not yet begun.
Interventional, Randomized, Parallel, Open label, Treatment purpose. Autism Spectrum Disorder, Depressive Disorder, Anxiety Disorders; age from 11 Years; to 17 Years. Intervention: CBT-DAY (Cognitive Behavioral Therapy for Depression in Aut…. Compared with: Treatment-as-Usual (TAU) — Active Comparator. n = 140. 1 site: United States.
This is a planned randomized controlled trial comparing CBT-DAY to treatment-as-usual in autistic youth with depression. No results have been posted to the registry; this record describes the study design and planned enrollment only. Recruitment has not yet begun.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a planned trial registration with no results posted; enrollment has not yet begun, so no evidence on effectiveness exists yet.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07755137). This is a study registration, not published results. Lead sponsor: Children's Hospital Los Angeles. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 140 participants (ESTIMATED). Conditions: Autism Spectrum Disorder, Depressive Disorder, Anxiety Disorders. Interventions: BEHAVIORAL: CBT-DAY (Cognitive Behavioral Therapy for Depression in Autistic Youth); BEHAVIORAL: Treatment-as-Usual (TAU). Primary outcome measures: Change in depressive symptom severity , Baseline to week 24. Brief summary: The goal of this clinical trial is to learn if Cognitive Behavioral Therapy for Depression in Autistic Youth (CBT-DAY) can improve depressive symptoms and related mechanisms in autistic youth aged 11-17 years with depression receiving care in outpatient clinical settings. The main questions it aims to answer are: * Does CBT-DAY lead to greater reductions in depressive symptom severity compared to treatment-as-usual (TAU)? * Does CBT-DAY improve key mechanisms (emotional reactivity, self-esteem, and autism self-knowledge) associated with depression outcomes? Researchers will compare CBT-DAY versus treatment-as-usual (TAU) to see if CBT-DAY results in greater improvements in depressive symptoms and related outcomes. Participants will: * Complete baseline, mid-treatment, post-treatment, and 3-month follow-up assessments (surveys and interviews) * Be randomly assigned to receive either 12 weeks of CBT-DAY or treatment-as-usual * Participate in therapy sessions during the 12-week intervention period * Complete follow-up assessments three months after treatment to evaluate longer-term outcomes
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