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Heart Failure · Observational Study
ClinicalTrials.gov · August 19, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a clinical trial registry record for an ongoing observational study comparing 2D and 3D speckle-tracking echocardiography strain measurement agreement in heart failure patients with reduced or mildly reduced ejection fraction. No results are reported in this registry entry; the study is currently recruiting and the primary outcomes (Bland-Altman bias and limits of agreement) have not yet been analysed or published.
Observational. Heart Failure; age from 18 Years. Intervention: Heart failure with reduced ejection fraction (HFrEF) or mil…. Compared with: 2D speckle-tracking echocardiography for measurement of global longitudinal strain. n = 419. 5 sites: Italy.
This is a clinical trial registry record for an ongoing observational study comparing 2D and 3D speckle-tracking echocardiography strain measurement agreement in heart failure patients with reduced or mildly reduced ejection fraction. No results are reported in this registry entry; the study is currently recruiting and the primary outcomes (Bland-Altman bias and limits of agreement) have not yet been analysed or published.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is an active observational registry record with no reported results; it describes a planned comparison study that may yield useful measurement agreement data but remains in recruitment phase with outcomes unknown.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07741305). This is a study registration, not published results. Lead sponsor: Istituti Clinici Scientifici Maugeri SpA. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 419 participants (ESTIMATED). Conditions: Heart Failure. Primary outcome measures: Bland-Altman mean difference (bias) and the limits of agreement (LOA) in comparison with a clinically acceptable range (±6.5%) , At baseline. Brief summary: This study will compare two ultrasound techniques, 2D and 3D speckle-tracking echocardiography, for measuring how well the heart muscle contracts in patients with heart failure and reduced pumping function. While 2D global longitudinal strain (GLS) is widely used and has proven value in predicting outcomes, 3D GLS may provide a more complete assessment of heart function. Researchers will enroll 419 patients from seven cardiac rehabilitation hospitals in Italy and analyze heart ultrasound images using standardized equipment and software. The study will assess how closely 2D and 3D GLS measurements agree, identify factors that influence any differences, and determine whether 3D GLS better predicts the risk of death than 2D GLS.
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