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Biomarkers / Heart Failure · Journal article
Jsams Plus · July 30, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a protocol document describing a planned 4-month randomized trial comparing conventional moderate-to-high intensity resistance training (60–80% 1RM) against low-load blood flow restriction training (20–30% 1RM) in 52 patients with NYHA II–III heart failure. No results are yet available; the trial aims to assess NT-proBNP change as the primary outcome and functional, echocardiographic, and clinical secondary outcomes.
Randomized, prospective, parallel-group clinical trial. 52 patients with heart failure, NYHA functional class II–III. Intervention: Low-load resistance training combined with blood flow restriction (BFRRT: 20–30% 1RM, calibrated at 50% arterial occlusion pressure). Compared with: Conventional moderate-to-high intensity resistance training (CRT: 60–80% 1RM). n = 52.
Planned comparison of CRT (60–80% 1RM) versus BFRRT (20–30% 1RM at 50% arterial occlusion pressure) Sample size: 52 patients, NYHA II–III Intervention duration: 4 months supervised, with 8-month post-intervention follow-up
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This is a protocol document only; no clinical implications can yet be drawn. Once results are published, the trial may provide evidence on the relative safety and efficacy of blood flow restriction training as an alternative to conventional high-intensity rehabilitation in heart failure patients unable to tolerate high hemodynamic loads.
Protocol for a planned randomized trial with modest sample size (n=52) and a surrogate primary endpoint (NT-proBNP); no results yet reported.
As stated by the source record.
Quoted from the source exactly as published.
This is a protocol document only; no clinical implications can yet be drawn. Once results are published, the trial may provide evidence on the relative safety and efficacy of blood flow restriction training as an alternative to conventional high-intensity rehabilitation in heart failure patients unable to tolerate high hemodynamic loads.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background. Heart failure (HF) significantly reduces functional capacity and quality of life in patients classified as New York Heart Association (NYHA) functional class II-III. While cardiopulmonary rehabilitation (CR) is beneficial, innovative strategies are required to improve accessibility and effectiveness for individuals unable to tolerate high hemodynamic loads.Aims. To compare the effects of conventional moderate-to-high intensity resistance training (CRT) versus low-load resistance training combined with blood flow restriction (BFRRT) on clinical, functional, and biochemical outcomes in HF patients.Methods and analysis. This randomized, prospective, parallel-group clinical trial will include 52 patients (NYHA II-III) allocated into CRT (60-80% 1RM) or BFRRT (20-30% 1RM, calibrated at 50% arterial occlusion pressure) groups. The supervised intervention lasts 4 months, with an 8-month post-intervention follow-up. The primary outcome is the change in serum NT-proBNP levels. Secondary outcomes include quality of life, echocardiographic ventricular function, functional capacity, and clinical events. Advanced statistical models and exploratory machine learning analyses with k-fold cross-validation will be utilized for predictive modeling and exploring personalized medicine strategies.Implications. The REHAB-WASHOUT HF trial aims to establish an effective, safe, and accessible therapeutic approach for HF rehabilitation, potentially enhancing clinical outcomes and guiding personalized prescriptive strategies in cardiovascular rehabilitation.Ethics and registration. Approved by the local institutional review board (No. 5.848.965; CAAE 64955022.9.1001.0029). Trial registration: RBR-5y8k7d7.
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