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Regulation of Appetite and Obesity · Review
World Journal of Advanced Research and Reviews · August 6, 2026
Reinforces what was already believed, rather than introducing something new.
This meta-analysis of six controlled trials found no statistically significant effect of the Modified Atkins Diet on serum leptin, adiponectin, or ghrelin levels in individuals with overweight, obesity, or metabolic syndrome. High heterogeneity among studies and inconsistent adiponectin findings limit confidence in the null result. The evidence base remains insufficient to establish metabolic benefit via adipokine regulation.
Systematic review and meta-analysis of controlled trials. Studies of patients with overweight, obesity, or metabolic syndrome receiving the Modified Atkins Diet compared to a control intervention.. Intervention: Modified Atkins Diet (a less restrictive ketogenic diet). Compared with: Control intervention (not specified in abstract).
MAD did not significantly affect serum leptin (MD = -2.68; 95% CI = -7.94 to 2.57) MAD did not significantly affect adiponectin (MD = -0.34; 95% CI = -0.83 to 0.15) MAD did not significantly affect ghrelin (MD = -57.55; 95% CI = -115.24 to 0.14)
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians should not expect the Modified Atkins Diet to produce meaningful changes in serum adipokine levels (leptin, adiponectin, ghrelin) as a mechanism for metabolic improvement in patients with overweight, obesity, or metabolic syndrome. The null findings and high heterogeneity suggest metabolic benefits, if any, may operate through different pathways or require different dietary approaches.
A systematic review and meta-analysis of six controlled trials showing no statistically significant effect of Modified Atkins Diet on adipokine markers, confirming the absence of a robust metabolic benefit in this population.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians should not expect the Modified Atkins Diet to produce meaningful changes in serum adipokine levels (leptin, adiponectin, ghrelin) as a mechanism for metabolic improvement in patients with overweight, obesity, or metabolic syndrome. The null findings and high heterogeneity suggest metabolic benefits, if any, may operate through different pathways or require different dietary approaches.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background: Overweight, obesity, and metabolic syndrome are associated with adipose tissue dysfunction and altered adipokine secretion. The Modified Atkins Diet (MAD), a less restrictive ketogenic diet, may improve metabolic health and regulate adipokines, but evidence remains inconsistent. This study evaluated the effects of MAD on serum leptin, adiponectin, and ghrelin levels. Methods: A systematic review and meta-analysis was conducted according to PRISMA 2020. PubMed, Scopus, and Web of Science were searched in May 2026. Studies were selected using predefined PICO criteria. Risk of bias was assessed using RoB 2 and ROBINS-I. A random-effects model was used, and outcomes were expressed as mean differences (MDs) with 95% confidence intervals (95% CIs). Results: Six studies were included. MAD did not significantly affect serum leptin (MD = -2.68; 95% CI = -7.94 to 2.57), adiponectin (MD = -0.34; 95% CI = -0.83 to 0.15), or ghrelin (MD = -57.55; 95% CI = -115.24 to 0.14). Although leptin and ghrelin tended to decrease, adiponectin findings were inconsistent. High heterogeneity was observed across all outcomes. Conclusion: Current evidence does not demonstrate a statistically significant effect of MAD on serum leptin, adiponectin, or ghrelin levels in individuals with overweight, obesity, and metabolic syndrome. Larger, well-designed studies with more homogeneous populations, longer intervention durations, and standardized methodologies are needed to clarify these effects.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.