Regulatory & drug approvals

OCT 24, 2026 · JOURNAL ARTICLE

Coordinated regulation of nuclear integrity and STING trafficking by miR-30d suppresses innate immunity in breast cancer

Nature Communications

Immune evasion is a key driver of tumour evolution and a major barrier to effective cancer therapy, frequently arising through suppression of the cytosolic DNA-sensing cGAS–STING p

OCT 23, 2026 · JOURNAL ARTICLE

Accelerator-based BNCT as a drug–device regimen: system engineering, clinical evidence, and regulatory considerations

Frontiers in Oncology

Boron neutron capture therapy (BNCT) is a binary, tumor-selective radiotherapy modality that combines preferential delivery of boron-10 to tumor tissue with neutron irradiation to

OCT 23, 2026 · JOURNAL ARTICLE

CPNE8 Suppresses Hepatocellular Carcinoma Progression Through Downregulation of ITGB1/CDC42/PAK1 Signaling and an Altered Immune-Marker Profile

Discovery Medicine

Background: Hepatocellular carcinoma (HCC) is among the most lethal malignancies, and its immunosuppressive microenvironment limits the efficacy of current therapies. The integrin

JOURNAL ARTICLE

Britanin improved high-fat diet-induced obesity by regulating the MAPK signaling pathway.

Pakistan Journal of Pharmaceutical Sciences

Single-center animal study with mechanistic validation but no human data, uncontrolled design, and surrogate endpoints only; insufficient for clinical guidance despite sound experimental approach.

JOURNAL ARTICLE

An Overview of Programmable Epigenetic Editing Based on CRISPR Tools for Gene Expression Regulation.

Methods in Molecular Biology

Epigenetic regulation provides a dynamic and reversible layer of gene control that functions independently of changes in DNA sequence, primarily mediated by DNA methylation, histon