Neurology & Alzheimer's

SEP 9, 2026 · OBSERVATIONAL STUDY

PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors

ClinicalTrials.gov

This is an active observational registry record with no reported results; it describes an ongoing study designed to characterize biomarkers and outcomes in sepsis survivors.

SEP 9, 2026 · PHASE 1 TRIAL

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD)

ClinicalTrials.gov

This is a Phase 1 clinical trial registry record with no results posted; it describes planned safety and tolerability assessment in a small early-stage cohort.

SEP 9, 2026 · PHASE 2 TRIAL

Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis

ClinicalTrials.gov

This is a recruiting Phase 2 trial with no results posted; it describes a planned study of repotrectinib in a specific population but carries no efficacy or safety data yet.

SEP 9, 2026 · PHASE 3 TRIAL

Effect of Hydralazine on Alzheimer's Disease

ClinicalTrials.gov

This is a completed Phase 3 trial registration with no results posted; the registry record describes design and rationale only, precluding any evidence assessment of efficacy.

SEP 9, 2026 · PREPRINT

An Explainable Machine Learning Framework for Predicting Blood-Brain Barrier Permeability Using Molecular Descriptors

arXiv

This is an unreviewed preprint presenting a machine learning model for predicting BBB permeability from molecular descriptors; it is methodologically sound but lacks peer review and clinical validation.

SEP 9, 2026 · PHASE 2 TRIAL

Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder

ClinicalTrials.gov

Phase 2 trial registration with no results posted; study is actively recruiting and designed to assess efficacy and safety of tirzepatide in binge-eating disorder.

SEP 9, 2026 · PHASE 1/2 TRIAL

Personalized Ultrasonic Brain Stimulation for Depression

ClinicalTrials.gov

Phase 1/2 uncontrolled feasibility study of a novel device with surrogate endpoints (MRI activation, mood scales); no results reported in this registry record.

SEP 9, 2026 · OBSERVATIONAL STUDY

Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease

ClinicalTrials.gov

This is a completed observational study with no posted results, examining associations between cerebrospinal fluid mitochondrial biomarkers and stroke outcomes using a small sample and surrogate biomarker measurements rather than hard clinical endpoints.