Genomics & gene therapy

DEC 1, 2026 · JOURNAL ARTICLE

Refining Genetic Instruments for Dietary Intake Mendelian Randomization Using Phenome-Wide Association Studies.

Genetic Epidemiology

Most Mendelian randomization (MR) of dietary intake use the full set of genome-wide significant (GWS) variants in the instrumental variable (IV), likely biasing causal estimates du

OCT 24, 2026 · JOURNAL ARTICLE

Spatial transcriptomics landscape of livers from patients with metabolic dysfunction-associated steatohepatitis

Genome Medicine

Metabolic dysfunction-associated steatohepatitis (MASH) progression involves heterogeneous responses and coordinated interactions among parenchymal and nonparenchymal cells. Single

OCT 23, 2026 · JOURNAL ARTICLE

Polygenic risk for type 2 diabetes modulates gut microbiome associations across metabolic health traits

npj Genomic Medicine

Abstract In this study, we integrated phenotype data, genotyping, and gut metagenomic data to investigate how genetic predisposition to T2D interacts with the gut microbiome, as we

OCT 23, 2026 · JOURNAL ARTICLE

RNA editing as an epitranscriptomic immune switch in tumor immunity and cancer immunotherapy

Journal of Translational Medicine

RNA editing is a dynamically regulated posttranscriptional mechanism that expands transcriptomic diversity and modulates cellular phenotypes. Accumulating evidence indicates that R

JOURNAL ARTICLE

Protocol for Detecting and Sequencing Chikungunya Virus from Field-Collected Mosquitoes.

Methods in Molecular Biology

Arboviral diseases represent a major public health challenge, especially in tropical regions where environmental conditions may favor the proliferation and spread of mosquito vecto

JOURNAL ARTICLE

Methodological Approaches for the Preservation of Akkermansia muciniphila as Microbial Genetic Resource.

Methods in Molecular Biology

Akkermansia muciniphila is part of the intestinal microbiota and uses mucin as its primary source of carbon and nitrogen. It is considered a promising next-generation probiotic, wi

JOURNAL ARTICLE

An Overview of Programmable Epigenetic Editing Based on CRISPR Tools for Gene Expression Regulation.

Methods in Molecular Biology

Epigenetic regulation provides a dynamic and reversible layer of gene control that functions independently of changes in DNA sequence, primarily mediated by DNA methylation, histon

JOURNAL ARTICLE

Nucleofection-Based CRISPR/Cas Delivery in Human T Cells for Immunotherapy Applications.

Methods in Molecular Biology

Electroporation-based delivery of CRISPR/Cas systems has emerged as a powerful and versatile approach for gene editing in primary human T cells, enabling efficient, transient, and