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Life sciences · Preprint
arXiv · September 16, 2026
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Generative artificial intelligence (GenAI) is changing how students learn, yet the roles of course context, cognitive reliance, evaluation literacy, and early reliance remain underexplored. Using survey responses from 118 students across 12 AI-related courses at our institution, we examined differences in GenAI use and perceived learning experiences. We identified four user clusters: high-use students reporting many benefits, light users reporting less reliance and fewer benefits, and two moderate-use groups reporting different levels of benefit. We also found significant differences between free- and premium-version users, single- and multiple-tool users, and students experiencing different instructor policies. In multivariable regression models, academic benefit was associated with early reliance and academic task support; positive impact was associated with cognitive reliance, academic task support, confidence in GenAI reliability, and instructor policy; and negative impact was associated with early reliance and attitudinal change. The association between early reliance and negative impact became stronger as evaluation literacy increased. Finally, perceptions of GenAI-enhanced learning appear to reflect cognitive, performance, and self-efficacy benefits, while concerns about stress and diminished critical thinking are associated with lower perceived learning benefits. These findings suggest that institutions need better policies to address such inequities so that institutions can enable students to benefit from increasingly capable AI systems.