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Life sciences · Preprint
arXiv · October 9, 2026
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Low-bit inference on accelerators with native 4-bit support requires quantizing both weights and activations to realize the full throughput gains these formats provide. While post-training weight quantization has been extensively studied, activation quantization remains considerably more challenging and typically requires calibration data. In this work, we introduce DUALQUANT, a dual-scale, calibration-free post-training quantization framework that directly minimizes the weight-reconstruction Mean Squared Error (MSE) and, as an immediate by-product, yields per-channel activation rescalings prior to activation quantization. Our key observation is that the scaling factors obtained by minimizing weight-reconstruction error provide effective activation rescalings, enabling competitive activation quantization without calibration data. We formulate DUALQUANT as a non-differentiable weight-reconstruction problem and develop an efficient solver based on variable splitting and block coordinate descent, where each subproblem admits a closed-form update. DUALQUANT provides a unified algorithm supporting a wide range of formats, including the full MX family and NVFP4. To our knowledge, DUALQUANT is the first dual-scaling method to formally support MX and NV block formats. Across Llama and Qwen models evaluated on WikiText-2, C4, and zero-shot downstream tasks, DUALQUANT matches or exceeds the accuracy of calibration-based SmoothQuant across most models and formats, and substantially outperforms calibration-free baselines, with large gains for MX and NV block formats. We validate these gains with a real packed W4A4 inference path for Llama-3.1-8B on an RTX 4090. The resulting implementation closely matches the accuracy of fake quantization while delivering up to 2.61x memory reduction and up to 2.46x throughput speedup over BF16.