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Life sciences · Journal article
International Journal of Drug Delivery Technology · October 9, 2026
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Background: Hypertension and overweight/obesity are major modifiable cardiovascular risk factors associated with oxidative stress, endothelial dysfunction, chronic inflammation, and increased risk of coronary artery disease.High-Intensity Interval Training (HIIT) has been recognized as an effective non-pharmacological intervention for improving cardiovascular and metabolic health.However, intense exercise may transiently increase oxidative stress and inflammatory responses.Ajwa dates (Phoenix dactylifera L.), which are rich in antioxidants and antiinflammatory compounds, may provide complementary protective effects against exercise-induced oxidative stress.Objective: This literature review aimed to evaluate the potential synergistic effects of Ajwa date supplementation combined with HIIT on oxidative stress and cardiovascular parameters in overweight hypertensive individuals.Methods: A narrative literature review was conducted using recent scientific articles published within the last five years from international databases related to hypertension, obesity, HIIT, oxidative stress, endothelial function, inflammation, and Ajwa dates.Relevant studies including clinical trials, systematic reviews, meta-analyses, and experimental studies were analyzed and synthesized.Results: The reviewed literature demonstrated that HIIT significantly improves blood pressure, endothelial function, aerobic capacity, body composition, and lipid metabolism in overweight and hypertensive populations.However, HIIT may also increase reactive oxygen species (ROS), inflammatory cytokines, and oxidative stress biomarkers.Ajwa dates contain polyphenols, flavonoids, vitamins, minerals, and dietary fiber with potent antioxidant and antiinflammatory properties that may reduce oxidative stress, improve vascular function, and support cardiovascular health.The combination of HIIT and Ajwa date supplementation may provide complementary cardiovascular and metabolic benefits while attenuating exercise-induced oxidative stress.Conclusion: HIIT combined with Ajwa date supplementation represents a promising integrative approach for improving cardiovascular and metabolic health in overweight hypertensive individuals.Further randomized controlled trials are needed to confirm its long-term efficacy and safety.