Respiratory Muscle Training / Head and Neck Cancer / Breast Carcinoma · Interventional Study

Home-based Respiratory Muscle Training for Minimizing Side Effects in Patients Undergoing Treatment for Cancer

ClinicalTrials.gov · August 19, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a recruiting feasibility and adherence study registered on ClinicalTrials.gov that proposes to evaluate home-based respiratory muscle training in cancer patients undergoing active treatment. No results are yet reported in this registry record. The study measures participation, retention, and session adherence as primary outcomes, not clinical efficacy or side-effect reduction.

What was studied

Interventional, Randomized, Parallel, Open label, Supportive Care purpose. Breast Carcinoma, Head and Neck Cancer, Lung Cancer; age from 21 Years. Intervention: Group II (Moderate to highter resistance RMT). Compared with: Group I (low resistance RMT Group) — Active Comparator. n = 130. 1 site: United States.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

Results are not yet available. Once reported, this feasibility study may inform whether home-based respiratory muscle training is acceptable and adherence-compatible for cancer patients, but clinicians should not infer clinical benefit until efficacy outcomes are measured and reported.

Plain-language summary

This is a registry record of a recruiting interventional study with no reported results; primary outcomes measure feasibility and adherence, not clinical efficacy.

Study design

As stated by the source record.

MethodsPrimary outcome measures: Proportion of patients who participate in the study (assessed at Up to 12 weeks); Proportion of patients who remain on study (assessed at Up to 12 weeks); Proportion of patients who perform >= 3 respiratory muscle training (RMT) sessions/week (assessed at Up to 12 weeks); Proportion of patients who perform > 70% of their RMT sessions (assessed at Up to 12 weeks)

DesignInterventional, Randomized, Parallel, Open label, Supportive Care purpose

PopulationBreast Carcinoma, Head and Neck Cancer, Lung Cancer; age from 21 Years

Sample size130

InterventionGroup II (Moderate to highter resistance RMT)

ComparatorGroup I (low resistance RMT Group) — Active Comparator

Setting1 site: United States

Reported figures

Quoted from the source exactly as published.

Planned enrollment130

Primary outcome measure 1Proportion of patients who participate in the study, up to 12 weeks

Primary outcome measure 2Proportion of patients who remain on study, up to 12 weeks

Primary outcome measure 3Proportion of patients who perform ≥3 respiratory muscle training sessions/week, up to 12 weeks

Primary outcome measure 4Proportion of patients who perform >70% of their RMT sessions, up to 12 weeks

Clinical bottom line

Caveats

Results are not yet reported in this registry record.
Primary outcomes measure feasibility and adherence only; no clinical side-effect outcomes are specified as primary.
Study design details (control group, blinding, randomisation) are not described in the registry record.
Across three different cancer types with estimated 130 total participants; heterogeneous population.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

limited

Interventional study; phase not specified; no control group described in registry.

Directness

limited

Primary outcomes are feasibility and adherence, not clinical side-effect or quality-of-life outcomes.

Consistency

insufficient

No results reported; cannot assess consistency with other evidence.

Risk of bias

insufficient

Registry record only; methods and blinding status not detailed.

Sample adequacy

limited

Estimated enrollment 130 participants across three cancer types; underpowered for clinical outcomes.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT05787834). This is a study registration, not published results. Lead sponsor: Roswell Park Cancer Institute. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 130 participants (ESTIMATED). Conditions: Breast Carcinoma, Head and Neck Cancer, Lung Cancer. Interventions: OTHER: Best Practice; OTHER: Medical Device Usage and Evaluation; PROCEDURE: Respiratory Muscle Training; OTHER: Survey Administration. Primary outcome measures: Proportion of patients who participate in the study , Up to 12 weeks; Proportion of patients who remain on study , Up to 12 weeks; Proportion of patients who perform >= 3 respiratory muscle training (RMT) sessions/week , Up to 12 weeks; Proportion of patients who perform > 70% of their RMT sessions , Up to 12 weeks. Brief summary: This clinical trial evaluates whether home-based respiratory muscle training is useful for minimizing side effects in patients undergoing treatment for cancer. Over-activation of the nervous system during breast cancer treatment can result in heart- and lung-related side effects which have the potential to reduce a patient's quality of life. Aerobic exercise can help prevent the development of these side effects. However, engaging in regular aerobic exercise may be difficult for breast cancer patients who are actively undergoing treatment. Respiratory muscle training (RMT) involves a series of breathing and other exercises that are performed to improve the function of the respiratory muscles through resistance and endurance training. Home-based RMT may represent a more feasible approach for reducing side effects in patients undergoing treatment for breast cancer.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Respiratory Muscle TrainingNCT05787834Head and Neck CancerBreast CarcinomaMedical Device Usage and EvaluationLung CancerRoswell Park Cancer InstituteSurvey AdministrationBest Practice