Loading
Life sciences · Journal article
Science · November 5, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Adipose tissue undergoes extensive remodeling to adapt to changing physiological demands. This plasticity encompasses changes in adipocyte metabolism and number, extracellular matrix organization, vascularization, immune composition, and innervation. When coordinated, these processes preserve energy buffering, thermogenesis, endocrine function, and local tissue support. Pathological adipose tissue remodeling drives obesity-related complications and contributes to many diseases involving organ-associated adipose depots throughout the body. In cancer, tumor-associated fat can develop a metabolic and fibroinflammatory niche that promotes tumor growth and invasion, and remodeling of other depots can directly disrupt neighboring tissues. Recent studies have identified mesenchymal, immune, vascular, and adipocyte states that govern adaptive or pathological outcomes. These findings broaden therapeutic goals beyond reducing fat mass toward restoring adipogenesis, substrate turnover, thermogenic capacity, and tissue-niche function.