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Leukemia / Breast Cancer / Prostate Cancer · Observational Study
ClinicalTrials.gov · August 5, 2026
Early or partial results. Treat as a signal, not a conclusion.
ELEA is a prospective observational cohort study registering 64,277 adult children of Agricultural Health Study participants to investigate associations between early-life agricultural exposures and cancer incidence. This is a study protocol registration with no results yet reported; outcome data will emerge from planned 5-year enrollment and ongoing follow-up linked to health registries.
Observational. Prostate Cancer, Leukemia, Breast Cancer, Melanoma, Colorectal Cancer; age from 18 Years; to 99 Years; accepts healthy volunteers. Intervention: Biological and Adopted Children of parents was formerly in…; Male and Women; Participants who can read and understand consent form; Participants who spent time on a farm; Pregnant Women. n = 64,277. 1 site: United States.
ELEA is a prospective observational cohort study registering 64,277 adult children of Agricultural Health Study participants to investigate associations between early-life agricultural exposures and cancer incidence. This is a study protocol registration with no results yet reported; outcome data will emerge from planned 5-year enrollment and ongoing follow-up linked to health registries.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Results from this study may provide evidence linking early-life agricultural exposures to cancer and other diseases in adulthood; however, no clinical data are available from this registry record. Clinicians should monitor for publication of findings to inform counseling of patients with occupational or familial agricultural exposure history.
This is a prospective observational cohort study registration with no results reported; it describes planned enrollment and follow-up for cancer incidence in children of agricultural workers, but outcome data are not yet available.
As stated by the source record.
Quoted from the source exactly as published.
Results from this study may provide evidence linking early-life agricultural exposures to cancer and other diseases in adulthood; however, no clinical data are available from this registry record. Clinicians should monitor for publication of findings to inform counseling of patients with occupational or familial agricultural exposure history.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07328516). This is a study registration, not published results. Lead sponsor: National Cancer Institute (NCI). Recruitment status: ENROLLING_BY_INVITATION. Study type: OBSERVATIONAL. Enrollment: 64277 participants (ESTIMATED). Conditions: Prostate Cancer, Leukemia, Breast Cancer, Melanoma, Colorectal Cancer. Primary outcome measures: Incidence of Cancer , Enrollment over 5 years, ongoing follow-up for life or until study end. Brief summary: Study Description: ELEA is an observational cohort study that will collect exposure information and biospecimens from the adult children of the Agricultural Health Study (AHS) cohort (https://aghealth.nih.gov/about; Protocol OH93NCN013). The primary hypothesis is that early life exposures, particularly those found in the agricultural environment, are associated with cancer and other adverse health outcomes in childhood and early adulthood. Eligible individuals will be invited to complete an online questionnaire. After enrollment, study participants may be asked to donate biological and environmental samples. Participants will be followed for cancer and other disease endpoints. Data will be collected from North Carolina and Iowa health registries, disease specific databases, the National Death Index (NDI), North Carolina and Iowa state health registries, publicly available environmental datasets, discarded sample repository, and collection of available samples. Investigators will access data and biospecimens from the AHS protocol OH93NCN01 and link it to the ELEA population. In an earlier ELEA protocol (16CN095) the NCI SS IRB approved the protocol to perform linkages. That protocol was closed after the transition to the NIH IRB (per a NHSR determination), but the linkage work continued under the ELEA protocols that remained open with Westat and Iowa. Objectives: Primary: To investigate the effect of specific pesticides and other agricultural exposures and risk of cancer in children and adults. Secondary: To investigate the effect of non-agricultural exposures and the risk of cancer and other diseases in children and adults. Exploratory: Exploratory objectives include, but are not limited to, the examination of genetic and various molecular biomarkers in relation to childhood agricultural exposures. Endpoints: Primary: Incidence of Cancer Secondary: Incidence of diseases other than cancer, survival, and various molecular biomarkers. ...
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.