Mental Stress / Congestive Heart Failure · Interventional Study

Stress and Congestive Heart Failure

ClinicalTrials.gov · August 18, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a completed interventional study registered at ClinicalTrials.gov examining whether acute mental stress precipitates CHF exacerbation. No results are posted in this registry record, so the efficacy, safety, or direction of any effect cannot be evaluated from this source alone.

What was studied

Interventional, Single Group, Open label, Basic Science purpose. Congestive Heart Failure; age from 18 Years. Intervention: Mental Stress. n = 108. 2 sites: United States.

Key findings

Safety

Results are not posted in this registry record; no efficacy, safety, or effect size data are available. Follow-up duration is 6 months for primary outcome; longer-term safety or durability unknown.

Who this may help

The source did not state who this applies to in practice.

Plain-language summary

This is a completed registry record with no posted results; the study examined stress and CHF exacerbation in 108 participants but outcome data are not reported here.

Study design

As stated by the source record.

MethodsPrimary outcome measure: Pulmonary Artery Pressure (assessed at 6 months)

DesignInterventional, Single Group, Open label, Basic Science purpose

PopulationCongestive Heart Failure; age from 18 Years

Sample size108

InterventionMental Stress

Setting2 sites: United States

Reported figures

Quoted from the source exactly as published.

Planned enrollment108

Primary outcome measurePulmonary Artery Pressure at 6 months

Recruitment statusCOMPLETED

Caveats

Results are not posted in this registry record; no efficacy, safety, or effect size data are available.
Study phase is listed as NA; study design details (blinding, control arm, randomization) not reported.
Comparator intervention not specified in registry summary.
Follow-up duration is 6 months for primary outcome; longer-term safety or durability unknown.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Interventional study design stated; phase not specified; no control arm described.

Directness

moderate

Direct investigation of acute stress and CHF exacerbation; patient population is CHF.

Consistency

insufficient

No results reported in registry record; cannot assess consistency.

Risk of bias

insufficient

Registry record lacks methods, blinding status, allocation details, or comparator.

Sample adequacy

moderate

108 completed participants enrolled; adequacy for primary outcome unknown.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT04551560). This is a study registration, not published results. Lead sponsor: Yale University. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 108 participants (ACTUAL). Conditions: Congestive Heart Failure. Interventions: OTHER: Mental Stress. Primary outcome measures: Pulmonary Artery Pressure , 6 months. Brief summary: The purpose of this study is to investigate whether acute stress can precipitate congestive heart failure (CHF) exacerbation in patients with CHF.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Mental StressNCT04551560Yale UniversityCongestive Heart Failure