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Life sciences · Interventional Study
ClinicalTrials.gov · September 22, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07834762). This is a study registration, not published results. Lead sponsor: University of California, San Diego. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 74 participants (ESTIMATED). Conditions: Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD). Interventions: DEVICE: Spaced Transcranial Direct Current Stimulation (tDCS); DEVICE: Sham Spaced tDCS. Primary outcome measures: Active vs Sham spaced tDCS Efficacy as measured by the Montgomery-Åsberg Depression Rating Scale , Baseline to 4-weeks post treatment. Brief summary: This study aims to evaluate the clinical efficacy and neurophysiological mechanisms of home-based spaced tDCS in TRD through a randomized, double-blind, sham-controlled trial conducted under remote supervision. Specifically, this trial will: (1) compare the efficacy of active versus sham spaced tDCS on depressive symptom severity in individuals with TRD and (2) characterize neurophysiological changes associated with spaced tDCS using TMS-EEG, TMS-EMG and resting state EEG.