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Life sciences · Journal article
International Journal of Clinical Case Reports and Reviews · October 6, 2026
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Background: Patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) unsuitable for curative treatment require effective palliative therapy aimed at symptom relief and quality-of-life (QOL) improvement. This study compared two hypo fractionated palliative radiotherapy regimens: the Quad Shot and Christie schedules. Methods: In this prospective randomized comparative interventional study, seventy eligible patients were randomly assigned in a 1:1 ratio to receive either the Quad Shot regimen (Arm A) or the Christie schedule (Arm B) using simple randomization by draw of lots. Radiotherapy was delivered using a Cobalt-60 teletherapy unit. Tumor response, toxicities, performance status, and QOL were assessed using the University of Washington Quality of Life Questionnaire Version 4. Results: Both regimens achieved comparable tumor response rates, with partial response observed in most patients. The Christie schedule demonstrated a higher nodal complete response rate. Toxicities were generally manageable, although grade 3 mucositis was more frequent in the Christie arm. Significant post-treatment improvement in performance status and multiple QOL domains was noted in both groups. Median overall survival was slightly higher with the Christie schedule. Conclusion: Both Quad Shot and Christie schedules are effective hypofractionated palliative radiotherapy regimens for incurable locally advanced HNSCC. While the Christie schedule showed a trend toward better nodal response and survival, the Quad Shot regimen offers the advantage of shorter treatment duration, making it a practical option for selected patients.