Regulation of Cues Enhanced / Behavioral Weight Loss / Overweight and Obesity · Interventional Study

Solutions for Hunger And Regulating Eating

ClinicalTrials.gov · September 10, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a completed interventional study registered at ClinicalTrials.gov comparing three behavioral interventions (Regulation of Cues Enhanced, active comparator, and Behavioral Weight Loss) in overweight and obese adults high in food responsiveness. No efficacy results are posted in this registry record; the study tracks body mass index change over 18 months as the primary outcome.

What was studied

Interventional, Randomized, Parallel, Single masking, Treatment purpose. Overweight and Obesity; age from 18 Years; to 65 Years. Intervention: Regulation of Cues Enhanced Treatment. Compared with: Behavioral Weight Loss — Active Comparator; Nutrition, Stress Management, and Social Support — Active Comparator. n = 293. 1 site: United States.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

The source did not state who this applies to in practice.

Plain-language summary

This is a completed registry record with no results posted; it describes a planned interventional study on behavioral weight management with enrollment completed but outcomes not yet reported.

Study design

As stated by the source record.

MethodsPrimary outcome measure: Change in Body Mass Index (assessed at Change from baseline at an average of 6 months, 9 months, 12 months, 15 months,…)

DesignInterventional, Randomized, Parallel, Single masking, Treatment purpose

PopulationOverweight and Obesity; age from 18 Years; to 65 Years

Sample size293

InterventionRegulation of Cues Enhanced Treatment

ComparatorBehavioral Weight Loss — Active Comparator; Nutrition, Stress Management, and Social Support — Active Comparator

Setting1 site: United States

Reported figures

Quoted from the source exactly as published.

Sample size293

Primary outcome measureChange in Body Mass Index

Follow-up duration6, 9, 12, 15, and 18 months

Caveats

Results are not posted in this registry record; efficacy data are not yet publicly available.
Blinding status, allocation concealment, and other methodological details are not described in the registry record.
No effect sizes, confidence intervals, or p-values are reported.
Comparison between the three arms and relative efficacy cannot be assessed from the registry record alone.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Interventional study with multiple behavioral arms; phase not specified.

Directness

moderate

Primary outcome is body mass index change; clinically relevant but surrogate measure.

Consistency

insufficient

No results reported; consistency cannot be assessed from registry record.

Risk of bias

insufficient

Registry record does not describe blinding, allocation concealment, or other bias mitigation.

Sample adequacy

moderate

293 participants enrolled across three behavioral intervention arms.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT05004883). This is a study registration, not published results. Lead sponsor: University of California, San Diego. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 293 participants (ACTUAL). Conditions: Overweight and Obesity. Interventions: BEHAVIORAL: Regulation of Cues Enhanced; BEHAVIORAL: Behavioral Weight Loss; BEHAVIORAL: Nutrition Education, Stress Management and Social Support. Primary outcome measures: Change in Body Mass Index , Change from baseline at an average of 6 months, 9 months, 12 months, 15 months, and 18 months. Brief summary: The objective of this proposed study is to collect efficacy data on ROC+ compared to an active comparator (AC) and to Behavioral Weight Loss (BWL) for participants who are high in Food Responsiveness.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Regulation of Cues EnhancedNCT05004883Behavioral Weight LossOverweight and ObesityUniversity of California, San DiegoNutrition Education, Stress Management and Social Support