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Life sciences · Interventional Study
ClinicalTrials.gov · October 27, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT04549155). This is a study registration, not published results. Lead sponsor: Duke University. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 37 participants (ACTUAL). Conditions: Mild Cognitive Impairment. Interventions: DEVICE: Transcranial Magnetic Stimulation. Primary outcome measures: Episodic Memory Task Performance , Baseline + Follow-up session, at day 3; Change in Representational Strength of Episodic Memories , Baseline + Follow-up session, at day 3. Brief summary: The proposed research will test a novel network-based neurostimulation approach using MRI-derived measures of brain connectivity to establish target sites for neurostimulation and test for the enhancement of memory function beyond a sham stimulation condition. This will be tested in cohort of MCI adults using network-based transcranial magnetic stimulation (TMS) to assess for behavioral improvement due to the controlled intervention. This study will provide important evidence towards the efficacy of neuromodulatory treatments for memory decline and will accelerate the discovery of potent non-invasive treatments to remediate cognitive decline in cognitively impaired older adults.