Life sciences · Phase EARLY_PHASE1 Trial
ClinicalTrials.gov · October 16, 2026
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Phase EARLY_PHASE1 Trial.
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Registry record from ClinicalTrials.gov (NCT04846829). This is a study registration, not published results. Lead sponsor: University of California, Los Angeles. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: EARLY_PHASE1. Study type: INTERVENTIONAL. Enrollment: 30 participants (ESTIMATED). Conditions: Major Depressive Disorder. Interventions: DRUG: Placebo; DEVICE: intermittent theta burst stimulation; DRUG: intravenous citalopram hydrochloride (CIT); DEVICE: continuous theta burst stimulation. Primary outcome measures: Percent change in Hamilton Depression Scale , through study completion, an average of 10 days. Brief summary: This study will recruit 30 subjects diagnosed with Major Depressive Disorder (MDD). Subjects will be recieve one infusion treatment of citalopram or placebo and 10 treatments of a form of transcranial magnetic stimulation, theta burst stimulation (TBS). Subjects will also undergo brain scans, quantitative electroencephalography (qEEG) brain activity recordings, and mood surveys. Study activities will be performed over the course of 4 weeks.