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Neurotransmitter Receptor Influence on Behavior / Cancer, Stress, Anesthesia, and Immune Response · Journal article
International Journal of Molecular Sciences · August 11, 2026
Raises a question worth testing. It does not answer one.
This is a narrative review that compiles existing knowledge about drugs and substances known to interact with TCTP and proposes repurposing opportunities based on TCTP's diverse cellular functions. The work is exploratory and hypothesis-generating rather than confirmatory; it identifies mechanistic interactions without testing clinical efficacy or outcomes.
Journal article.
TCTP plays a role in cell growth, cell cycle regulation, cellular proliferation, allergic reactions, stress response, apoptosis inhibition, calcium ion binding, microtubule and actin microfilament interactions, cancer progression, and tumor reversion. Numerous drugs and chemicals have been demonstrated to interact with TCTP.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This review should be read as a conceptual synthesis identifying candidates for further mechanistic and translational investigation. Readers should not use TCTP-interaction status alone as evidence for clinical efficacy; each proposed repurposing requires independent validation.
A narrative review compiling known drug-TCTP interactions to propose repurposing opportunities; raises questions about therapeutic potential rather than testing clinical efficacy.
This review should be read as a conceptual synthesis identifying candidates for further mechanistic and translational investigation. Readers should not use TCTP-interaction status alone as evidence for clinical efficacy; each proposed repurposing requires independent validation.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no reported figures. That is a gap in the analysis, not a judgement about the study.
Thanks to the rapid development of advanced analytical methods, researchers can now identify new, so far unknown applications for existing drugs. This expanding knowledge about the mechanisms of drug action, including interactions with various molecules and molecular pathways, not only enables more effective use of available therapies but also reduces both the time and cost of developing new therapeutic options. One of the proteins reported to interact with numerous drugs and chemicals is Translationally Controlled Tumor Protein (TCTP). Numerous studies have demonstrated that TCTP plays a crucial role in diverse biological processes, including cell growth, cell cycle regulation, cellular proliferation, allergic reactions, stress response, inhibition of apoptosis, calcium ion binding, interacting with microtubules and actin microfilaments, the progression of various cancers, and tumor reversion. Therefore, this review article aims to compile a list of drugs and substances shown to interact with TCTP and that, given TCTP’s numerous cellular functions, could be repurposed for other therapies.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.