Loading
Life sciences · Journal article
Frontiers in Pediatrics · September 17, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Background Acute leukemia (AL) is the most common malignancy in childhood. Despite significant improvements in survival rates, long-term high-intensity chemotherapy often leads to severe physical dysfunction and cancer-related fatigue (CRF) in pediatric patients. Although exercise intervention is a significant non-pharmacological physical therapy for improving patient prognosis, clinical practice still lacks unified, evidence-based standardized guidance. Objective To systematically retrieve, evaluate, and synthesize evidence regarding exercise interventions for children with AL, providing a decision-making reference for multidisciplinary clinical teams to develop standardized and individualized exercise rehabilitation programs. Methods Guided by the Joanna Briggs Institute (JBI) evidence-based practice framework, a comprehensive search was conducted in domestic and international databases, including UpToDate, BMJ Best Practice, JBI, PubMed, Cochrane Library, CNKI, and Wanfang, to identify clinical decision supports, guidelines, expert consensuses, systematic reviews, and meta-analyses related to exercise interventions for pediatric AL. The search period spanned from database inception to January 2026. Methodological quality appraisal and data extraction were performed independently by two researchers. Results Eighteen publications were included, consisting of 2 clinical practice guidelines and 16 systematic reviews. Seventeen items of best evidence were extracted, covering eight dimensions: intervention principles, safety, exercise modalities, intensity, frequency and timing, stage-specific strategies, intervention settings, and outcome improvement. Conclusion Children with acute leukemia should engage in long-term, individualized, multimodal exercise interventions under professional supervision. Healthcare professionals should dynamically adjust exercise protocols based on the specific treatment phase. While ensuring safety, incorporating game-based formats can enhance patient adherence, thereby effectively improving bone mineral density, cardiorespiratory endurance, and quality of life. Systematic Review Registration https://www.crd.york.ac.uk/prospero/view/CRD420261341113/1/0, PROSPERO CRD420261341113.