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Inflammatory Bowel Diseases / Biomarkers / Circular Rna · Journal article
Rna Biology · June 15, 2026
Early or partial results. Treat as a signal, not a conclusion.
This narrative review consolidates early evidence that circRNAs exhibit altered expression in IBD patients and may regulate JAK/STAT, NF-κB, Wnt, PI3K/AKT, and Hippo pathways implicated in disease pathogenesis. The authors propose circRNAs as candidate diagnostic and therapeutic targets, but mechanistic validation remains preliminary and clinical utility is unproven.
Narrative review. IBD patients (Crohn's disease and ulcerative colitis) and healthy controls; studies cited involve colon tissue and peripheral blood mononuclear cell samples.
163 upregulated circRNAs and 55 downregulated circRNAs identified in colon tissue of CD patients versus healthy controls 155 upregulated and 229 downregulated circRNAs detected in PBMCs from CD patients compared with healthy controls AUC of has_circRNA_004662 is 0.85 for CD diagnosis; expression higher in CD than UC (p<0.001) but not different between UC and healthy controls (p=1.00)
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians should recognize circRNAs as an emerging research area with potential for future diagnostic and therapeutic applications in IBD, but clinical translation is premature; current therapeutic decisions remain based on established biologics and small molecules.
This is a narrative review synthesizing early-stage research on circRNAs in IBD pathogenesis; no primary experimental or clinical data are presented, and evidence remains exploratory with limited mechanistic validation.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians should recognize circRNAs as an emerging research area with potential for future diagnostic and therapeutic applications in IBD, but clinical translation is premature; current therapeutic decisions remain based on established biologics and small molecules.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder of the gastrointestinal tract with a complex aetiology involving genetic, environmental (such as diet/lifestyle), and microbiota factors. The exact pathogenesis of IBD remains unclear, and current therapies show limited effectiveness. Circular RNAs (circRNAs) are a novel class of noncoding RNAs that have been implicated in the regulation of various biological processes. Many circRNAs show specific expression profiles in IBD patients and play important roles in IBD pathogenesis through different signalling pathways, such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and nuclear factor-κB (NF-κB) pathways. Although research on circRNAs in IBD is still in its early stages, many circRNAs have emerged as potential diagnostic, prognostic biomarkers, and therapeutic targets for IBD. Here, we summarize the molecular functions and underlying mechanisms of circRNAs in IBD and discuss current challenges and future perspectives for clinical applications.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.