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Ultrasound Imaging and Elastography / Liver Disease Diagnosis and Treatment · Journal article
The Turkish Journal of Gastroenterology · August 17, 2026
Encouraging direction, but not yet definitive.
This pilot case–control study demonstrates that pancreatic stiffness measured by 2D-SWE is significantly elevated in patients with type 2 diabetes compared with healthy controls and is associated with metabolic factors (obesity, waist circumference, pancreatic steatosis) rather than microvascular complications. The finding is based on a small, single-centre cohort and uses a surrogate imaging endpoint; clinical relevance and generalizability remain to be established.
Prospective case–control pilot study. 45 patients with type 2 diabetes mellitus and 45 healthy controls; specific clinical setting, age range, and full eligibility criteria not specified.. Intervention: 2-dimensional shear wave elastography measurement of pancreatic stiffness. Compared with: Healthy controls (no diabetes). n = 90.
Pancreatic stiffness significantly higher in T2DM patients than controls across all pancreatic regions (P <.001) Pancreatic stiffness did not differ significantly between T2DM patients with and without microvascular complications (P >.05) Pancreatic steatosis more prevalent in T2DM than healthy controls (P =.001)
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This pilot work identifies pancreatic stiffness as a potential imaging biomarker for metabolic pancreatic alterations in type 2 diabetes, linked to obesity rather than microvascular complications. Clinicians should await larger, multicentre validation studies and assessment of whether pancreatic stiffness predicts clinical outcomes (e.g., progression to pancreatic disease) before considering incorporation into routine practice.
A prospective case–control pilot study with clear group differences in pancreatic stiffness (P <.001) and metabolic associations, but limited by small sample size, single-centre setting, surrogate imaging endpoint, and lack of clinical outcome validation.
As stated by the source record.
Quoted from the source exactly as published.
This pilot work identifies pancreatic stiffness as a potential imaging biomarker for metabolic pancreatic alterations in type 2 diabetes, linked to obesity rather than microvascular complications. Clinicians should await larger, multicentre validation studies and assessment of whether pancreatic stiffness predicts clinical outcomes (e.g., progression to pancreatic disease) before considering incorporation into routine practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background/Aims: Shear wave elastography (SWE) is a noninvasive method for assessing tissue stiffness. This study evaluated pancreatic stiffness in patients with type 2 diabetes mellitus (T2DM) and examined its association with metabolic factors and microvascular complications. Materials and Methods: This prospective case–control study included 45 patients with T2DM and 45 healthy controls. Pancreatic stiffness was measured using 2-dimensional SWE (2D-SWE). Clinical, anthropometric, and laboratory data were collected, and diabetic microvascular complications were assessed. Results: A total of 90 participants were included, comprising 45 patients with T2DM and 45 healthy controls. Pancreatic stiffness was significantly higher in patients with T2DM than in controls across all pancreatic regions (P <.001). However, pancreatic stiffness did not differ significantly between patients with T2DM with and without microvascular complications (P >.05). Pancreatic steatosis (PS) was more prevalent in patients with T2DM than in healthy controls (P =.001). Among patients with T2DM, pancreatic stiffness was significantly higher in those with steatosis than in those without (P =.035), and stiffness increased with the severity of steatosis (P =.021). Body mass index and waist circumference (WC) were independently associated with increased pancreatic stiffness, with WC accounting for a significant proportion of the variance (P <.001). Conclusion: Pancreatic stiffness was significantly higher in patients with T2DM than in healthy controls and was primarily associated with metabolic factors, particularly obesity and PS, rather than microvascular complications. These findings suggest that increased pancreatic stiffness may reflect metabolic associated pancreatic alterations. Cite this article as: İnce YE, Sezgin O, Yaraş S, Özdoğan O, Gen. Pancreatic stiffness in patients with type 2 diabetes mellitus assessed by 2-dimensional shear wave elastography: A pilot case–control study. Turk J Gastroenterol. Published online August 17, 2026. doi: 10.5152/tjg.2026.25617
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.