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Life sciences · Journal article
International Journal of Pharmacological and Pharmaceutical Innovations · September 25, 2026
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Background: Herbal medicines are widely investigated as supportive approaches for metabolic disorders because of their chemically diverse phytoconstituents and multitarget pharmacological potential. The present work was designed specifically as a formulation-development and quality-characterization study. A polyherbal tablet formulation incorporating hydroalcoholic extracts of Terminalia arjuna and Withania somnifera was formulated and subjected to systematic standardization. The developed formulation was assessed through pharmacognostic and physicochemical characterization, phytochemical screening, TLC fingerprint profiling, and evaluation of relevant tablet quality attributes. No in-vitro, in-vivo, or clinical anti-obesity efficacy experiment was performed in the present study; therefore, anti-obesity relevance is discussed only as a rationale for future pharmacological evaluation. Methods: The selected medicinal plants were authenticated and subjected to pharmacognostic, physicochemical, and phytochemical evaluations. Hydroalcoholic extracts were prepared and characterized using preliminary phytochemical screening and thin-layer chromatography (TLC) for qualitative standardization. Polyherbal tablets were formulated by the direct compression technique using suitable pharmaceutical excipients. The prepared tablets were evaluated for organoleptic characteristics, weight variation, hardness, thickness, friability, and disintegration time according to pharmacopeial guidelines. The developed formulation was further assessed for its overall pharmaceutical quality and suitability as a standardized herbal dosage form. Results: Pharmacognostic investigations confirmed the authenticity and quality of the selected plant materials. Physicochemical analysis and phytochemical screening demonstrated the presence of important bioactive constituents, including flavonoids, tannins, alkaloids, phenolics, glycosides, and saponins. TLC fingerprinting produced distinct chromatographic profiles, supporting the identity and consistency of the herbal extracts. The formulated tablets exhibited acceptable physicochemical characteristics with uniform weight distribution, adequate hardness, low friability, appropriate thickness, and satisfactory disintegration time, indicating good mechanical strength and manufacturing quality. Conclusion: The developed polyherbal tablet demonstrated satisfactory pharmaceutical quality and successful phytochemical standardization, supporting its potential as a stable herbal formulation for future anti-obesity applications. The findings provide a scientific foundation for further investigations involving advanced analytical standardization, dissolution profiling, stability studies, and clinical evaluation to establish its therapeutic efficacy.