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Life sciences · Journal article
Cell Surface · July 9, 2026
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This is a narrative review of fucoidan research and biotechnology that identifies knowledge gaps and proposes technical and research directions to advance the field. It does not present new empirical or clinical evidence, but rather contextualizes existing literature on fucoidan bioactivities (antiviral, anticancer, immunomodulatory, haemostatic) and suggests future research priorities for brown algae biology and seaweed biotechnology.
Journal article. Brown algae (macroalgae); not a clinical study population.
Fucoidans account for approximately 9–14% of the total dry weight of brown algae Fucoidans mediate physiological functions in brown algae including cell desiccation resistance, cell adhesion, cell elongation, cell differentiation, and cell fate decisions Known bioactivities of fucoidans include antiviral, anticancer, regulation of immune responses, and haemostasis properties
No specific therapeutic efficacy, dosing, or safety data are reported
The source did not state who this applies to in practice.
This is a narrative review article that synthesizes existing knowledge and proposes future research directions on fucoidans; it raises questions about fucoidan biology and biotechnology rather than presenting new empirical evidence or clinical results.
Quoted from the source exactly as published.
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Fucoidans, also known as fucose-containing sulfated polysaccharides (FCSPs), are abundant and structurally complex glycans found in the cell wall of brown algae. These compounds have been shown to have fundamental roles in the development and physiology of these organisms, to provide a major contribution to marine carbon sequestration, and to exhibit numerous bioactivities. Despite this, we currently have a limited understanding of the metabolic pathways and enzymes involved in synthesis and remodelling of fucoidans, their spatial and temporal dynamics in brown algae and in the marine environment, and how their structure and composition influence their bioactivities. Here, we highlight some of the challenges that have hindered progress on fucoidan research. We then moved on to underline some of the recent technical progress and new resources that would contribute to alleviate these challenges when combined together. This includes new technical approaches in analytical chemistry and glycobiology, as well the extension of genomic resources and genetics tools for brown algae. Finally, we suggest how progress in fucoidan research should contribute to advance understanding on brown algae biology, while supporting current and developing new aspects in fucoidan applications and seaweed biotechnology as part of the growing blue bioeconomy.
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