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Life sciences · Interventional Study
ClinicalTrials.gov · October 29, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07903896). This is a study registration, not published results. Lead sponsor: Hartford Hospital. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 75 participants (ESTIMATED). Conditions: Depressed Mood, Young Adults, Heat Stress, Sleep. Interventions: OTHER: Heat/Humidity Exposure Condition; OTHER: Thermoneutral Condition. Primary outcome measures: PANAS-10 , periprocedurally* measures collected during lab weekends (i.e. periprocedurally) ONLY - marked with " * "; POMS-8 [depression subscale of POMS-60] , periprocedurally*; PHQ-9 , baseline, pre-intervention, periprocedurally; GAD-7 , baseline, pre-intervention, periprocedurally; Qualitative Experience , immediately after intervention*. Brief summary: The goal of this clinical trial is to learn how hot indoor temperatures affect mood in young adults with depression, with or without anxiety. It will also explore whether the time of day the heat happens matters, and whether changes in sleep, thinking, and daily activity help explain the effect. The main questions it aims to answer are: * Does heat during the day affect mood differently than heat at night? * Do changes in sleep, thinking, or activity help explain those effects? Researchers will compare a weekend that is hot during the day to a weekend that is hot at night to see how the timing of heat affects mood. Participants will take part for about four weeks. During that time, participants will: * Stay in a sleep lab for two weekends, two weeks apart. Each stay runs from Friday afternoon to Monday midday. * Spend one weekend in rooms that are hot (32°C, or 90°F) from 8 in the morning to 8 at night, and comfortable (22°C, or 72°F) overnight * Spend the other weekend in rooms that are comfortable (22°C, or 72°F) during the day and hot (32°C, or 90°F) overnight * Be woken up at 2 in the morning on the last night of each lab stay. Participants will answer questions and do short thinking tasks, then go back to sleep. * Wear sensors that track their sleep, heart rate, and body temperature, and swallow a small capsule that measures body temperature from the inside * Answer questions about their mood and do short thinking tasks, both in the lab and at home * Use a phone app for the whole four weeks of the study. The app asks about mood and sleep, and works with the sensors to track sleep, movement, heart rate, temperature, and humidity.