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Life sciences · Preprint
arXiv · September 26, 2026
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Learning transferable representations for dynamic text-attributed graphs (DyTAGs) requires models to capture underlying interaction dynamics that persist across domains. However, existing methods tend to overfit to domain-specific structural, temporal, and semantic patterns, limiting edge classification performance under distribution shifts. To expose and address this, we formally establish a leave-one-domain-out (LODO) transfer learning protocol for edge classification on DyTAGs. Under this protocol, we demonstrate that state-of-the-art self-supervised methods for dynamic graph learning perform poorly when transferred to unseen domains. Strikingly, existing methods underperform a structurally and temporally unaware Bag of Events (BoE) model we introduce, which inputs only unordered sequences of node and edge text features. Proceeding from the BoE, we propose Spatio-Temporal Semantic Alignment (STSA), which integrates a spatio-temporal encoder that fuses representations of time deltas and node occurrence frequencies into a unified manifold. STSA is trained with a Contrastive Semantic Forecasting objective, which anchors edge representations to a multi-domain textual latent space initialized by a pretrained language model, providing a robust prior that outperforms BoE and all existing methods we evaluate.