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Life sciences · Journal article
International Journal of Physiology · September 11, 2026
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Background: Obesity is showed as increase body fat which poses risk of insulin resistance (IR), dyslipidaemia, cell organelles stress, vascular inflammation & metabolic dysregulation. Altogether an altered lipid metabolism and oxidative stress associated with obesity and affect the nerve conduction velocity (NCV). Motor and Sensory nerve conduction velocity (MNCV & SNCV) is a routine electrodiagnostic technique for detecting any changes in nerve conduction parameters (Distal Motor Latency, Compound Muscle Action potential, Sensory Nerve Action Potential, Conduction Velocity). Few studies reported delayed or prolongation of distal latency and other parameters like CMAP& CV observed reduced accordance to some investigator while other studied observed either decrease or no changes in conduction velocity with changes in BMI.Aim: The aim of this study was to assess the relationship between NCV and Body Mass Index (BMI)Materials and Methods: This Cross-Sectional study was conducted among one hundred twenty-five (125) students of Gauhati medical college, categorized according to their Body mass index (BMI)as underweight, normal weight, overweight and obese. Median nerve conduction studies were performed in the Neurophysiology Laboratory of the Department of Physiology with the help of Neuroperfect machine. Correlation analysis was applied to assess the relationship between BMI and Nerve conduction velocity parameters.Results: We observed significant positive correlation between BMI categories and latency of right(r-value=0.642) & left(r-value=0.582) Median NCV. Negative correlation between BMI category with CMAP, CV and SNAP parameters of median NCV. Conclusion: The results of this study suggest that nerve function in healthy individuals may vary with increasing BMI. Higher BMI appears to be associated with changes in nerve conduction parameters, indicating that excess body weight can influence peripheral nerve performance. Hence, further studies required larger sample sizes and more comprehensive investigative methods.