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Life sciences · Observational Study
ClinicalTrials.gov · October 9, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07565610). This is a study registration, not published results. Lead sponsor: Itshak Amsalem. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 150 participants (ESTIMATED). Conditions: Obesity, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction (HFPEF). Primary outcome measures: Change in intramyocardial fat content assessed by cardiac CT , Baseline to 6 months. Brief summary: The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity. The main questions it aims to answer are: Does fat inside the heart muscle decrease after weight loss surgery? Does heart relaxation (diastolic function) improve after surgery? Are changes in heart fat linked to changes in weight, body fat, and blood markers? Participants who are already planning to have weight loss surgery will take part in this study. Participants will: Have a heart CT scan to measure fat in the heart muscle before surgery and about 6 months after surgery Have an ultrasound of the heart (echocardiogram) to check how the heart fills and relaxes Have body composition testing to measure fat and muscle Have blood tests, including routine tests and additional markers related to heart function and metabolism Researchers will compare each participant's results before and after surgery to see if heart fat decreases and if heart function and blood markers improve.