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Life sciences · Observational Study
ClinicalTrials.gov · October 27, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07541677). This is a study registration, not published results. Lead sponsor: Singapore General Hospital. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 160 participants (ACTUAL). Conditions: Obesity. Primary outcome measures: Sarcopenia , Outcome measures will be recorded at baseline only.; Handgrip strength , Outcome measures will be recorded at baseline only.; 5-time chair stand test , Outcome measures will be recorded at baseline only.; 30-second sit-to-stand test , Outcome measures will be recorded at baseline only.. Brief summary: Sarcopenia, a condition where individuals lose muscle mass and strength, is associated with poorer health and function. While aging is a well-known cause of sarcopenia, obesity is increasingly recognised as a significant factor. When sarcopenia and obesity occur together, it can result in more severe health problems. This is especially concerning because weight loss, the treatment for obesity, can further reduce muscle mass and potentially worsen the situation. Despite this, it is unknown how common sarcopenia is among people with obesity, as only a few studies have looked into this using the most accurate diagnostic criteria, showing a prevalence of 4-13%. In this study, the investigators will examine the prevalence of sarcopenia in 300 adults with obesity at a specialized Obesity Center. The investigators expect to find a higher prevalence among Asian participants due to differences in body composition compared to other ethnic groups. The investigators will also explore various factors that might be linked to sarcopenia in these individuals, such as age, gender, race, body mass index, smoking and alcohol use, medical conditions, medications, physical activity, aerobic capacity, and dietary protein intake. Some of these factors could help in identifying those at risk of sarcopenia and could be targeted for future treatments. Currently, screening for sarcopenia is not a standard part of routine obesity care as it requires specialized equipment and trained staff. By determining how common sarcopenia is in people with obesity, this study will help healthcare providers better understand the problem and allocate resources effectively. Identifying factors associated with sarcopenia will also help streamline diagnosis and monitoring for those at risk.