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Life sciences · Phase 2 Trial
ClinicalTrials.gov · October 8, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Phase 2 Trial.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT07219875). This is a study registration, not published results. Lead sponsor: University of California, Los Angeles. Recruitment status: RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 80 participants (ESTIMATED). Conditions: Positive Affect, Depression. Interventions: BEHAVIORAL: Virtual Reality-Reward Training (VR-RT); BEHAVIORAL: Virtual Reality-Memory Training (VR-MT). Primary outcome measures: The Mood and Anxiety Symptoms Questionnaire - Anhedonic Depression Subscale (MASQ-AD) , Week 0 (baseline), Week 3 (mid-training), Week 5 (post-training), and Week 9 (follow-up). Primary comparisons are change from Week 0 to Week 5 and from Week 0 to Week 9.; Positive Valence Systems Scale (PVSS-21) , Week 0 (baseline), Week 3 (mid-training), Week 5 (post-training), and Week 9 (follow-up). Primary comparisons are change from Week 0 to Week 5 and from Week 0 to Week 9.. Brief summary: The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. VR-RT is a novel intervention aimed at enhancing savoring of positive experiences among individuals with elevated depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology. Target enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 4 weeks of either VR-RT or VR-MT. Participants will complete in-person VR sessions, laboratory assessments, and self-report questionnaires as part of the study. The total length of participation is around 3 months.