Life sciences · Phase 2 Trial
ClinicalTrials.gov · November 5, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT07718672). This is a study registration, not published results. Lead sponsor: Roswell Park Cancer Institute. Recruitment status: RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Early Stage Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8. Interventions: PROCEDURE: Biospecimen Collection; PROCEDURE: Computed Tomography; PROCEDURE: Lymph Node Biopsy; PROCEDURE: Positron Emission Tomography; RADIATION: Stereotactic Body Radiation Therapy; RADIATION: Stereotactic Body Radiation Therapy; OTHER: Survey Administration. Primary outcome measures: Time to progression (local control) , Up to 2 years. Brief summary: This clinical trial compares stereotactic ablative radiotherapy (SBRT) with hot spots to standard of care SBRT for the treatment of patients with early-stage non-small cell lung cancer. SBRT with hot spots intentionally makes sure the tumor gets a higher radiation dose during treatment. This potentially may result in better control of the tumor, but also more side effects. SBRT with or without hot spots may be more effective in treating patients with early-stage non-small cell lung cancer, compared to standard of care SBRT.