Septic Shock / Fluid Reponsiveness · Observational Study

This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload

ClinicalTrials.gov · September 1, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a planned observational study comparing lung ultrasound and transthoracic echocardiography (LVOT VTI) for detection of fluid accumulation and fluid responsiveness in septic shock. No results have been posted; the record documents study design and planned outcomes only.

What was studied

Observational. Septic Shock, Fluid Reponsiveness; age from 18 Hours; accepts healthy volunteers. Intervention: Lung ultrasound for detection of fluid accumulation and fluid responsiveness.. Compared with: Transthoracic echocardiography using LVOT VTI.. n = 30. Ain Shams University (Egypt); single centre implied..

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

The source did not state who this applies to in practice.

Plain-language summary

This is a registry record for a planned observational study with no results posted; recruitment has not yet begun, making it a feasibility and design document only.

Study design

As stated by the source record.

MethodsCohort model. Prospective time perspective. Primary outcome measures: Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral versus lung ultrasound (assessed at 12 hours); Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral ursus lung ultrasound. (assessed at 12 hours)

DesignObservational

PopulationSeptic Shock, Fluid Reponsiveness; age from 18 Hours; accepts healthy volunteers

Sample size30

InterventionLung ultrasound for detection of fluid accumulation and fluid responsiveness.

ComparatorTransthoracic echocardiography using LVOT VTI.

SettingAin Shams University (Egypt); single centre implied.

Reported figures

Quoted from the source exactly as published.

Planned enrollment30

Primary outcome measurement timepoint12 hours

Study typeObservational

Caveats

Registry record only; results are not yet reported and recruitment has not begun.
Primary outcome measures stated ambiguously with apparent duplication; exact outcome definitions unclear.
No sample size justification, power calculation, or statistical analysis plan documented.
No comparator, control group, or blinding strategy described; observational design limits causal inference.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

limited

Observational design without randomization or control group specified.

Directness

insufficient

No results reported; primary outcomes stated but not yet measured.

Consistency

insufficient

Single-site, first study of this comparison; no prior data available.

Risk of bias

insufficient

Study methods and blinding not described; no results to assess bias.

Sample adequacy

limited

Estimated 30 participants; small sample for diagnostic accuracy comparison.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT07797751). This is a study registration, not published results. Lead sponsor: Ain Shams University. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 30 participants (ESTIMATED). Conditions: Septic Shock, Fluid Reponsiveness. Primary outcome measures: Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral versus lung ultrasound , 12 hours; Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral ursus lung ultrasound. , 12 hours. Brief summary: Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Septic ShockFluid ReponsivenessAin Shams UniversityNCT07797751