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Influenza Vaccines / Influenza Vaccine · Journal article
Expert Review of Vaccines · August 27, 2026
Reinforces what was already believed, rather than introducing something new.
This retrospective cohort study of 4,257 hospitalized adults aged ≥65 years with laboratory-confirmed influenza found influenza vaccination associated with a 26% relative risk reduction in in-hospital death (95% CI: 3–43%) but showed little or no protective effect against ICU admission (RRR 11%, 95% CI: −21–34%). The finding reinforces prior evidence that vaccination reduces severe fatal outcomes in older hospitalized influenza patients, though protection against critical illness requiring ICU care appears limited.
Retrospective cohort study. Adults aged ≥65 years hospitalized with laboratory-confirmed influenza, enrolled across five European I-MOVE hospital network sites over six influenza seasons (2015/16–2024/25); exclusion criteria applied but not fully detailed in abstract.. Intervention: Influenza vaccination (defined as vaccine receipt ≥14 days before symptom onset). Compared with: No influenza vaccination. n = 4,257. European I-MOVE hospital network, five sites, six seasons (2015/16–2024/25).
ICU admission occurred in 3% of vaccinated versus 5% of unvaccinated patients; RRR 11% (95% CI: −21–34) In-hospital death occurred in 5% of both vaccinated and unvaccinated patients; RRR 26% (95% CI: 3–43) For IHD, RRR was 17% in ages 65–79 years and 29% in ages ≥80 years
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians should counsel older hospitalized influenza patients that prior vaccination is associated with a modest but meaningful reduction in in-hospital mortality risk (~26%), though it does not substantially reduce ICU admission risk. This reinforces the importance of pre-season vaccination in older populations but suggests other interventions (e.g., antiviral therapy, supportive care) remain essential for preventing critical illness.
Retrospective cohort study of 4,257 hospitalized older adults showing vaccination associated with 26% relative risk reduction in in-hospital death (95% CI: 3–43%) but minimal effect on ICU admission; reinforces established benefit against severe mortality outcomes.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians should counsel older hospitalized influenza patients that prior vaccination is associated with a modest but meaningful reduction in in-hospital mortality risk (~26%), though it does not substantially reduce ICU admission risk. This reinforces the importance of pre-season vaccination in older populations but suggests other interventions (e.g., antiviral therapy, supportive care) remain essential for preventing critical illness.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Introduction. Older adults face an increased risk of influenza-related intensive care unit (ICU) admission and in-hospital death (IHD). Although vaccination reduces hospitalization, its effect on these outcomes remains uncertain. We estimated the association between influenza vaccination and both outcomes among adults aged ≥65 years hospitalized with laboratory-confirmed influenza.Research design and methods. We conducted a retrospective cohort study using European I-MOVE hospital network data (2015/16-2024/25); vaccination was defined as vaccine receipt ≥14 days before symptom onset. We estimated pooled-season adjusted risk ratios (aRR) using Poisson regression adjusting for potential confounders. We calculated relative risk reduction (RRR) as (1-aRR)×100, overall and by age group (65-79, ≥80 years).Results. After exclusions, 4,257 patients (five study sites, six seasons) were included. ICU admission occurred in 3% of vaccinated and 5% of unvaccinated patients; IHD occurred in 5% of both groups. RRR was 11% (95% CI: -21-34) against ICU admission (65-79 years: -4%; ≥80 years: 44%). RRR against IHD was 26% (95% CI: 3-43); 17% and 29% in each respective age group.Conclusions. Vaccination showed little or no association with ICU admission, but was associated with a one-quarter reduction in IHD among hospitalized older adults, reinforcing its benefits against fatal in-hospital outcomes.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.