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Compassion Focused Therapy / Bipolar Disorder / Ending Self Stigma · Interventional Study
ClinicalTrials.gov · August 19, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned interventional trial comparing group-based Compassion Focused Therapy and psychoeducation to treatment as usual for reducing self-stigma in patients with bipolar disorder, schizophrenia, depression, borderline personality disorder, or autism spectrum disorder. The study is currently recruiting and has not yet reported results; the primary outcome is internalized stigma measured by the ISMI inventory at baseline, 1 month, 2 months, and 3 months.
Interventional, Randomized, Parallel, Single masking, Treatment purpose. Bipolar Disorder, Schizophrenia, Depression, Borderline Personality Disorder, Autism Spectrum Disorder; age from 18 Years. Intervention: Compassion Focused Therapy. Compared with: Ending Self Stigma — Active Comparator; Treatment As Usual — No Intervention. n = 336. 7 sites: France.
Primary outcome measure: Internalized Stigma of Mental Illness inventory (ISMI) assessed at Day 0, Month 1, Month 2, and Month 3 Planned enrollment: 336 participants Conditions studied: Bipolar Disorder, Schizophrenia, Depression, Borderline Personality Disorder, Autism Spectrum Disorder
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
If positive results are reported, this trial could establish Compassion Focused Therapy as an evidence-based intervention for reducing internalized stigma across multiple psychiatric conditions, with implications for improving treatment adherence and recovery outcomes. Clinicians should await published results before integrating this approach into practice.
This is a clinical trial registry record with no reported results; the study is actively recruiting and designed to evaluate a behavioral intervention for self-stigma across five psychiatric conditions.
As stated by the source record.
Quoted from the source exactly as published.
If positive results are reported, this trial could establish Compassion Focused Therapy as an evidence-based intervention for reducing internalized stigma across multiple psychiatric conditions, with implications for improving treatment adherence and recovery outcomes. Clinicians should await published results before integrating this approach into practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Registry record from ClinicalTrials.gov (NCT05698589). This is a study registration, not published results. Lead sponsor: University Hospital, Strasbourg, France. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 336 participants (ESTIMATED). Conditions: Bipolar Disorder, Schizophrenia, Depression, Borderline Personality Disorder, Autism Spectrum Disorder. Interventions: BEHAVIORAL: Compassion Focused Therapy; BEHAVIORAL: Ending Self Stigma. Primary outcome measures: Internalized Stigma of Mental Illness inventory (ISMI) , Day 0; Internalized Stigma of Mental Illness inventory (ISMI) , Month 1; Internalized Stigma of Mental Illness inventory (ISMI) , Month 2; Internalized Stigma of Mental Illness inventory (ISMI) , Month 3. Brief summary: People with mental disorders face frequent stigmatizing attitudes and behaviors from others . In response to this, they tend to isolate themselves, with the risk of impeding care and the process of recovery and integration into society . Stigmatization can also be assimilated by patients themselves - i.e. self-stigma. Self-stigma is involved in diminished coping skills that lead to social avoidance and difficulties in adhering to care . Reducing self-stigma and its emotional corollary, shame, is thus crucial to attenuate the disability associated with mental illness. Shame is inherent to self-stigma and leads to difficulties in adhering to care as well as greater severity of clinical presentations . Compassion Focused Therapy (CFT) is a third wave cognitive behavioral therapy that targets shame reduction and hostile self-to-self relationship and allows for symptom improvement while increasing self-compassion, a major resilience factor . Although shame is a prominent part of the concept of self-stigma, the efficacy of CFT has never been evaluated in individuals with high levels of self-stigma. In this study, the investigators will evaluate the efficacy and acceptability of a group based CFT program on decreasing self-stigma, compared to treatment as usual (TAU) and a psychoeducation program whose efficacy has been assessed in a previous trial.
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