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Life sciences · Journal article
International Journal of Drug Delivery Technology · October 10, 2026
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The present study was undertaken to investigate the phytochemical profile and anti-obesity potential of Martynia annua leaves using physicochemical, phytochemical and in-vivo experimental approaches.Preliminary phytochemical screening of the extracts confirmed the presence of major secondary metabolites.Total phenolic content estimation by Folin-Ciocalteu method revealed that the methanolic extract of Martynia annua leaves possessed the highest phenolic content, indicating strong antioxidant potential.The anti-obesity activity was evaluated in high-fat diet (HFD) induced obese Wistar albino rats.Animals were divided into seven groups including normal control, HFD control, standard (orlistat), methanolic extract (150 and 300 mg/kg) and aqueous extract (150 and 300 mg/kg).Various parameters such as body weight, food intake, organ weights, serum lipid profile and liver function markers were assessed.HFD feeding produced significant weight gain, increased food intake, enlarged liver and adipose tissue, dyslipidemia and elevated liver enzymes.Treatment with Martynia annua leaf extracts significantly attenuated HFD-induced obesity.The methanolic extract at 300 mg/kg showed the most pronounced effect, producing a marked reduction in body weight, food intake and epididymal adipose tissue weight, comparable to the standard drug.The extract also significantly improved lipid profile by reducing triglycerides, total cholesterol and LDL levels while improving HDL levels.Furthermore, the extracts normalized liver enzyme levels (SGOT, SGPT and bilirubin), indicating hepatoprotective activity.Martynia annua leaves possess significant anti-obesity and antihyperlipidemic activity, particularly in methanolic extract form, which may be attributed to its high phenolic content.The study supports the potential of this plant as a natural therapeutic agent for the management of obesity and associated metabolic disorders.