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Life sciences · Phase 1/2 Trial
ClinicalTrials.gov · September 25, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Phase 1/2 Trial.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
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Registry record from ClinicalTrials.gov (NCT06700538). This is a study registration, not published results. Lead sponsor: Arrowhead Pharmaceuticals. Recruitment status: RECRUITING. Phase: PHASE1, PHASE2. Study type: INTERVENTIONAL. Enrollment: 180 participants (ESTIMATED). Conditions: Obesity. Interventions: DRUG: ARO-INHBE; DRUG: Placebo; DRUG: Tirzepatide. Primary outcome measures: Number of Participants with Treatment-Emergent Adverse Events (TEAEs) , Up to Day 365. Brief summary: This is a Phase 1/2a double-blind dose-escalating study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple doses of ARO-INHBE in adult participants with obesity (in Part 1), the safety, tolerability, PK, and PD of multiple doses of ARO-INHBE either as monotherapy, or in combination with tirzepatide, in adult participants with obesity with and without type 2 diabetes mellitus (in Part 2 and Part 3).