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Life sciences · Interventional Study
ClinicalTrials.gov · November 2, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07909525). This is a study registration, not published results. Lead sponsor: ECOG-ACRIN Cancer Research Group. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 448 participants (ESTIMATED). Conditions: Breast Ductal Carcinoma In Situ, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm. Interventions: OTHER: Best Practice; OTHER: Educational Intervention; OTHER: Informational Intervention; OTHER: Interview; OTHER: Survey Administration. Primary outcome measures: Change of financial hardship , Baseline up to 6 months after randomization; Change in health insurance literacy , Baseline up to 6 months after randomization. Brief summary: This clinical trial addresses the financial hardship among adolescent and young adult (AYA) survivors using the new Lessening the Impact of Financial Toxicity (LIFT) UP intervention. AYAs with cancer experience significant and prolonged disruption in their lives due to their diagnosis and are at greater risk of financial hardship than any other age group with cancer. For AYA patients, health insurance literacy - one's ability to make informed decisions about choosing and using health insurance - is likely an essential component of being able to navigate care and manage costs. A promising strategy for addressing AYA financial hardship is to streamline existing, successful interventions into a single multilevel intervention. More specifically, combining patient education from a health insurance literacy intervention called CHAT (Let's CHAT about health insurance), which helps to address the book knowledge with organization support and financial navigation from an intervention called LIFT, which addresses the experiential knowledge could yield positive outcomes for AYAs. The addition of LIFT UP to usual care may improve AYA access to financial resources and reduce medical costs and distress associated with financial hardship.