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Life sciences · Interventional Study
ClinicalTrials.gov · September 24, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07569133). This is a study registration, not published results. Lead sponsor: Ho-Won Lee. Recruitment status: ENROLLING_BY_INVITATION. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 50 participants (ESTIMATED). Conditions: Parkinson's Disease, Depression. Interventions: DEVICE: Repetitive Transcranial Magnetic Stimulation (rTMS); DEVICE: Sham Repetitive Transcranial Magnetic Stimulation (Sham rTMS). Primary outcome measures: Change From Baseline in Beck Depression Inventory-II (BDI-II) Total Score , Baseline, immediately after the final stimulation session, and 4 weeks (±7 days) after the final stimulation session; Change From Baseline in Neuropsychiatric Inventory (NPI) Scores , Baseline, immediately after the final stimulation session, and 4 weeks (±7 days) after the final stimulation session. Brief summary: The purpose of this study is to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in improving depressive symptoms in patients with Parkinson's Disease(PD). Participants will be randomly assigned to either an active rTMS group or a sham-control group. The study aims to evaluate the efficacy and feasibility of a neuronavigation-guided bilateral M1 rTMS protocol.