Life sciences · Preprint
arXiv · October 3, 2026
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Post-training quantization to the GGUF format's mixed-precision K-quants is commonly how open-weight language models reach consumer hardware, yet its effect on fine-grained lexical competence is uncharacterized. We audit 27 quantized artifacts across 13 families and four architecture backbones, 0.35B-14B parameters, evaluated down their published ladder to Q2_K (about 2.6 bits per weight), on 429 frequency-validated rare English words under two probes: surface inclusion of a prompt-supplied word and its one-sentence definition, scored by a tiered multi-synonym matcher, its error measured by a blind LLM-judge census of every definition, with human verification. Three regimes emerge at Q2: total collapse into unusable builds, severe semantic dissociation in sub-2B models, and mostly robust preservation above about 3B. In every sub-2B artifact, definitions fall 20-67% below the artifact's baseline, typically several times the inclusion loss. Two controls separate rarity from task difficulty: within the rare set, loss rises with rarity in six of seven sub-2B artifacts, and on a 100-word common-word set rare words lose more than common words in all eight, significantly in six. Tokenizer vocabulary size does not predict the damage (Spearman rho=0.12); parameter count dominates (rho=0.72), confirmed within five of six same-tokenizer families. Q4_K_M remains lexically clean at >=1B. The damage is frequency-graded, provider-dependent, and not calibrated by WikiText-2 perplexity: across nine artifact-matched ladders, near-identical Q2 penalties (44.7%/47.6%) separate an artifact keeping its definitions (3.6%) from one losing them (43.6%). Aggressively quantized small models can keep generating fluent text while no longer knowing what it means, risking hardware-constrained deployments in domains where semantics carries consequences. Validation must be per artifact.