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Alzheimer Disease / low carbohydrate/high fat diet / Mild Cognitive Impairment · Interventional Study
ClinicalTrials.gov · August 3, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a completed registry entry for a randomized dietary intervention trial (BEAT-AD) comparing ketogenic low-carbohydrate diet to low-fat diet in 84 adults with mild cognitive impairment over 16 weeks, with 8-week follow-up. No outcome results are reported in this registry record, and clinical significance cannot be assessed without posted findings.
Interventional, Randomized, Parallel, Double masking, Treatment purpose. Alzheimer Disease, Mild Cognitive Impairment; age from 55 Years; to 85 Years. Intervention: Modified Mediterranean Ketogenic Diet; American Heart Association Diet. Compared with: Low-fat/high-carbohydrate diet for 16 weeks. n = 84. 1 site: United States.
This is a completed registry entry for a randomized dietary intervention trial (BEAT-AD) comparing ketogenic low-carbohydrate diet to low-fat diet in 84 adults with mild cognitive impairment over 16 weeks, with 8-week follow-up. No outcome results are reported in this registry record, and clinical significance cannot be assessed without posted findings.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Results of this study, once posted, may inform whether ketogenic diet produces measurable changes in amyloid-β biomarkers and cognitive function in early cognitive decline. Clinicians should await full publication of outcomes before interpreting clinical utility.
This is a completed clinical trial registry record with no reported results; the study enrolled 84 participants with mild cognitive impairment randomized to ketogenic or low-fat diet over 16 weeks, but outcome data are not posted in this registry entry.
As stated by the source record.
Quoted from the source exactly as published.
Results of this study, once posted, may inform whether ketogenic diet produces measurable changes in amyloid-β biomarkers and cognitive function in early cognitive decline. Clinicians should await full publication of outcomes before interpreting clinical utility.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT03472664). This is a study registration, not published results. Lead sponsor: Wake Forest University Health Sciences. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 84 participants (ACTUAL). Conditions: Alzheimer Disease, Mild Cognitive Impairment. Interventions: OTHER: low carbohydrate/high fat diet; OTHER: low fat/high carbohydrate diet. Primary outcome measures: Cerebrospinal Fluid Abeta42 , baseline; Cerebrospinal Fluid Abeta42 , week 16. Brief summary: The Brain Energy for Amyloid Transformation in AD (Alzheimer's disease) or BEAT-AD study will compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment. The data collected will help determine whether diet interventions induce changes in cognitive function, cerebral blood flow, and levels of certain proteins and hormones in body fluids. The study will include volunteers who have mild cognitive impairment, who will be randomly assigned to receive either a ketogenic low-carbohydrate diet or a low-fat diet for 16-weeks, with follow-up assessment 8 weeks after diet completion. Study measures, clinic visits and phone sessions will occur at baseline and throughout the 24-week study. Participant will follow either a low-carbohydrate or low-fat diet that will be individually planned with help from a study dietitian. After completing the study diet for 16 weeks, participants will resume their normal diet. The final visits will occur at week 24 (8 weeks after the completing the diet). At the end of the 24-week study, participants will be given the opportunity to meet with the study dietitian for education and assistance with planning a healthy diet.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.