Loading
Cancer Diagnosis and Treatment · Journal article
Frontiers in Oncology · August 12, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a case report of a 43-year-old woman with gastric adenocarcinoma presenting with synchronous cutaneous and pineal metastases, treated with sequential individualized targeted regimens guided by multi-site biomarker testing. The case documents sustained disease stabilization and long-term survival but remains a single anecdotal observation of an extraordinarily rare metastatic pattern with no control group or comparative evidence.
Case report. One 43-year-old woman with advanced gastric adenocarcinoma and synchronous cutaneous and pineal metastases. Intervention: Sequential individualized targeted therapy regimens guided by variable biomarker status across metastatic sites.
Gastric adenocarcinoma metastasized simultaneously to skin and pineal gland in a 43-year-old woman Pineal metastases account for less than 1% of all adult intracranial tumors Variable biomarker status across metastatic sites guided sequential targeted therapy regimens
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
A single case report describing an extraordinarily rare metastatic pattern with anecdotal treatment response; raises questions about multi-site biomarker heterogeneity and sequential targeted therapy but provides no controlled evidence or generalizable outcomes.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Gastric adenocarcinoma simultaneously metastasizing to the skin and pineal gland represents an extraordinarily rare clinical manifestation. Pineal metastases account for less than 1% of all adult intracranial tumors and seldom originate from gastrointestinal primary lesions, and this atypical metastatic combination frequently results in delayed diagnosis and complicated clinical decision-making. Distinct molecular profiles between primary and metastatic lesions create additional obstacles to personalized treatment, and relevant standardized management strategies for such rare cases have not been well established. We describe a 43-year-old woman with advanced gastric adenocarcinoma complicated by synchronous cutaneous and pineal metastases. Pathological evaluation confirmed the gastric origin of the cutaneous lesions, while the pineal lesion was presumptively classified as metastatic based on molecular concordance and clinical context. Guided by variable biomarker status across metastatic sites, sequential individualized targeted regimens were delivered, yielding sustained disease stabilization and satisfactory long-term survival. This case supplements clinical data on rare distant metastatic patterns of gastric cancer and highlights that repeated multi-site genetic testing is essential to formulate precise therapeutic plans for heterogeneous advanced gastrointestinal malignancies.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.