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Life sciences · Journal article
International Journal of Advanced Research in Science Communication and Technology · October 15, 2026
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Localized anticancer patches are being investigated as drug-delivery platforms that may concentrate therapeutic agents at accessible tumors while limiting exposure of healthy tissues. Approaches discussed in this review include conventional topical patches, drug-in-adhesive and matrix systems, hydrogel reservoirs, dissolving microneedles, nanoparticle-enabled formulations, and implantable microneedle systems. Candidate materials include hyaluronic acid, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, chitosan, hydroxypropyl methylcellulose, ethyl cellulose, and adhesive polymers. Investigated payloads include 5-fluorouracil, doxorubicin, cisplatin, methotrexate, tamoxifen, natural-product extracts, and immunomodulators. Functional nanomaterials may provide additional capabilities such as controlled release, magnetic targeting, photothermal effects, or stimulus-responsive activation. It depends on safety, effectiveness and etc. Many advanced concepts remain at the preclinical or formulation-development stage, and clinical benefit should not be assumed without robust evidence. This review summarizes the principal patch designs, materials, payloads, potential advantages, limitations, and research priorities for localized cancer therapy. [1,2,4,7,12].