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Life sciences · Interventional Study
ClinicalTrials.gov · September 30, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07580508). This is a study registration, not published results. Lead sponsor: Universiti Putra Malaysia. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 870 participants (ESTIMATED). Conditions: Heart Failure, Chronic Heart Failure (CHF). Interventions: BEHAVIORAL: RE-AIM-informed autonomy-competence intervention. Primary outcome measures: Medication adherence (self-efficacy) in heart failure patients , 3 months; Medication adherence (objective adherence rate) , 3 months. Brief summary: Medication non-adherence leads to recurrent admissions, worsening symptoms, poor quality of life, and increased healthcare costs in an already overburdened health system. Existing adherence interventions in Pakistan are limited, mostly educational, and rarely guided by behavioural theory, implementation science, or economic evaluation. Therefore, a culturally appropriate, RE-AIM-informed autonomy-competence intervention is needed to improve medication adherence and quality of life among heart failure patients in Pakistan, while also assessing implementation feasibility and cost-effectiveness for future scale-up.