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Life sciences · Preprint
arXiv · November 4, 2026
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Reward alignment for diffusion- and flow-based generative models is often formulated over stochastic trajectories, making it less suitable for few-step deterministic generators. Initial noise optimization provides a trajectory-free alternative, but existing gradient-free methods require costly per-sample search at inference. We introduce LeNO (Learning Noise Optimization), which amortizes reward-guided initial noise optimization into a learned residual transport while keeping the pretrained generator frozen. LeNO learns an anchor-conditioned distribution over noise corrections using Local GRPO and scalar rewards, eliminating iterative test-time optimization. For Gaussian initial noise with norm-preserving projection, we derive a tractable upper bound on the KL divergence between the corrected noise distribution and the original prior, providing a principled regularization objective. We evaluate LeNO on few-step text-to-image and protein structure generation, including expensive black-box designability rewards. Across both domains, LeNO improves target rewards with a single noise correction at inference while largely preserving generation quality and diversity.